Challenges in Paediatric Xenotransplantation: Ethical Components Requiring Distinct Attention in Children and Obligations to Patients and Society.

IF 1.8 3区哲学 Q2 ETHICS

Journal of Bioethical Inquiry Pub Date : 2024-10-10 DOI:10.1007/s11673-024-10377-5

Anthony Merlocco, Daniel J Hurst

引用次数: 0

Abstract

The transplantation of non-human organs into humans, or xenotransplantation (XTx), has recently garnered new attention and is being developed to help address the problem of organ scarcity in transplantation. Ethical issues surrounding XTx have been studied since initial interest arose decades ago and have experienced renewed discussion in the literature. However, the distinct and relevant differences when applied to children has largely been overlooked with few groups attending to the concerns that XTx in children raises. In this paper, we explore ethical challenges to be expected in paediatric XTx, in particular exploring organ sizing concerns, infectious risks, psychological burdens, and issues of moral hazard. We review these domains with the aim of highlighting the implications of pursuing paediatric XTx and the cross-disciplinary approach needed to solve these issues. Children require a unique analysis from a bioethical perspective to best prepare for the issues XTx presents.

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儿科异种移植的挑战：需要特别关注儿童的伦理因素以及对患者和社会的义务。

将非人类器官移植到人类体内，或称异种器官移植（XTx），最近引起了新的关注，其发展有助于解决器官移植中器官稀缺的问题。自从几十年前人们对 XTx 产生兴趣以来，有关 XTx 的伦理问题一直在研究之中，文献中也再次对这些问题进行了讨论。然而，在儿童身上应用 XTx 时的明显相关差异在很大程度上被忽视了，很少有团体关注 XTx 在儿童身上应用所引发的问题。在本文中，我们将探讨儿童 XTx 可能面临的伦理挑战，特别是探讨器官大小问题、感染风险、心理负担和道德风险问题。我们回顾了这些领域，旨在强调开展儿童 XTx 的意义以及解决这些问题所需的跨学科方法。儿童需要从生命伦理学的角度进行独特的分析，以便为 XTx 带来的问题做好最佳准备。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bioethical Inquiry 医学-医学：伦理

CiteScore

5.20

自引率

8.30%

发文量

审稿时长

>12 weeks

期刊介绍： The JBI welcomes both reports of empirical research and articles that increase theoretical understanding of medicine and health care, the health professions and the biological sciences. The JBI is also open to critical reflections on medicine and conventional bioethics, the nature of health, illness and disability, the sources of ethics, the nature of ethical communities, and possible implications of new developments in science and technology for social and cultural life and human identity. We welcome contributions from perspectives that are less commonly published in existing journals in the field and reports of empirical research studies using both qualitative and quantitative methodologies. The JBI accepts contributions from authors working in or across disciplines including – but not limited to – the following: -philosophy- bioethics- economics- social theory- law- public health and epidemiology- anthropology- psychology- feminism- gay and lesbian studies- linguistics and discourse analysis- cultural studies- disability studies- history- literature and literary studies- environmental sciences- theology and religious studies