Emerging roles of antimicrobial peptides in innate immunity, neuronal function, and neurodegeneration.

IF 14.6 1区 医学 Q1 NEUROSCIENCES
Trends in Neurosciences Pub Date : 2024-11-01 Epub Date: 2024-10-09 DOI:10.1016/j.tins.2024.09.001
Soojin Lee, Neal Silverman, Fen-Biao Gao
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引用次数: 0

Abstract

Antimicrobial peptides (AMPs), a collection of small proteins with important roles in classical innate immunity, have been extensively studied in multiple organisms, particularly in Drosophila melanogaster. Advances in CRISPR/Cas9 genome editing have allowed individual AMP functions to be dissected, revealing specific and selective roles in host defense. Recent findings have also revealed many unexpected contributions of endogenous AMPs to neuronal functions and neurodegenerative diseases, and have shed light on the intersections between innate immunity and neurobiology. We explore the intricate relationships between AMPs and sleep regulation, memory formation, as well as traumatic brain injury and several neurodegenerative diseases such as Alzheimer's disease (AD), frontotemporal dementia (FTD), and Parkinson's disease (PD). Understanding the diverse functions of AMPs opens new avenues for neuroinflammation and neurodegenerative disease research and potential therapeutic development.

抗菌肽在先天性免疫、神经元功能和神经退化中的新作用。
抗菌肽(AMPs)是在经典先天性免疫中发挥重要作用的一系列小蛋白,已在多种生物,特别是黑腹果蝇中得到广泛研究。CRISPR/Cas9基因组编辑技术的进步使人们能够剖析单个AMP的功能,揭示其在宿主防御中的特异性和选择性作用。最近的发现还揭示了内源性 AMP 对神经元功能和神经退行性疾病的许多意想不到的作用,并阐明了先天免疫和神经生物学之间的交叉关系。我们探讨了 AMPs 与睡眠调节、记忆形成、创伤性脑损伤以及阿尔茨海默病(AD)、额颞叶痴呆(FTD)和帕金森病(PD)等多种神经退行性疾病之间错综复杂的关系。了解 AMPs 的多种功能为神经炎症和神经退行性疾病的研究以及潜在疗法的开发开辟了新的途径。
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来源期刊
Trends in Neurosciences
Trends in Neurosciences 医学-神经科学
CiteScore
26.50
自引率
1.30%
发文量
123
审稿时长
6-12 weeks
期刊介绍: For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.
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