Interstitial lung abnormality in COPD is inversely associated with the comorbidity of lung cancer.

IF 2.6 3区医学 Q2 RESPIRATORY SYSTEM

BMC Pulmonary Medicine Pub Date : 2024-10-10 DOI:10.1186/s12890-024-03311-3

Jianrui Zheng, Jiaxi Guo, Guangdong Wang, Liang Zhang, Xinhua Yu, Dehao Liu, Yikai Lin, Rongzhou Zhang, Aiping Ma, Xiuyi Yu

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Abstract

Background: Interstitial lung abnormality (ILA) has been recognized as a pertinent factor in the development and prognosis of various pulmonary conditions. However, its correlation with co-morbidities remains understudied. The current study endeavors to elucidate the association between ILA and both clinical features and co-morbidities in patients with chronic obstructive pulmonary disease (COPD).

Methods: A retrospective cohort comprising 1131 hospitalized patients diagnosed with COPD was examined in this observational study. Patients were dichotomously classified based on the presence or absence of ILA, and subsequent analyses scrutinized disparities in demographic, clinical, and laboratory profiles, alongside co-morbid conditions, between the two subgroups.

Results: Of the 1131 COPD patients, 165 (14.6%) exhibited ILA. No statistically significant differences were discerned between COPD patients with and without ILA concerning demographic, clinical, or laboratory parameters, except for levels of circulating fibrinogen and procalcitonin. Nevertheless, a notable discrepancy emerged in the prevalence of multiple co-morbidities. Relative to COPD patients devoid of ILA, those presenting with ILA manifested a diminished prevalence of lung cancer (OR = 0.50, 95% CI: 0.30-0.83, p = 0.006), particularly of the lung adenocarcinoma (OR = 0.32, 95% CI: 0.15-0.71, p = 0.005). Additionally, the presence of ILA in COPD was positively associated with heart failure (OR = 1.75, 95% CI: 1.04-3.00, p = 0.040) and cancers other than lung cancer (OR = 2.27, 95% CI: 1.16-4.39, p = 0.012).

Conclusion: These findings demonstrate that the presence of ILA is associated with co-morbidities of COPD, particularly lung cancer.

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慢性阻塞性肺病的肺间质异常与肺癌的合并症成反比。

背景：肺间质异常（ILA）已被认为是各种肺部疾病发病和预后的相关因素。然而，其与并发症的相关性仍未得到充分研究。本研究旨在阐明 ILA 与慢性阻塞性肺病（COPD）患者的临床特征和并发症之间的关系：本观察性研究对1131名被诊断为慢性阻塞性肺病的住院患者进行了回顾性队列研究。根据是否存在 ILA 对患者进行了二分法分类，随后的分析仔细研究了两个亚组之间在人口统计学、临床和实验室概况以及并发症方面的差异：在1131名慢性阻塞性肺病患者中，有165人（14.6%）表现出ILA。除循环纤维蛋白原和降钙素原水平外，有 ILA 和无 ILA 的慢性阻塞性肺病患者在人口统计学、临床或实验室参数方面均无明显差异。然而，在多种并发症的发病率方面却出现了明显的差异。与没有 ILA 的 COPD 患者相比，有 ILA 的患者肺癌发病率较低（OR = 0.50，95% CI：0.30-0.83，p = 0.006），尤其是肺腺癌（OR = 0.32，95% CI：0.15-0.71，p = 0.005）。此外，慢性阻塞性肺病患者体内的 ILA 与心力衰竭（OR = 1.75，95% CI：1.04-3.00，p = 0.040）和肺癌以外的癌症（OR = 2.27，95% CI：1.16-4.39，p = 0.012）呈正相关：这些研究结果表明，ILA的存在与慢性阻塞性肺病的并发症有关，尤其是肺癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Pulmonary Medicine RESPIRATORY SYSTEM-

CiteScore

4.40

自引率

3.20%

发文量

423

审稿时长

6-12 weeks

期刊介绍： BMC Pulmonary Medicine is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of pulmonary and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.