Ph₃P═O-Catalyzed Reductive Deoxygenation of Alcohols.

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2024-11-01 Epub Date: 2024-10-11 DOI:10.1021/acs.joc.4c01847

Qiang Li, Yu Sun, Mu-Xian Fu, Jin-Hong Lin, Ji-Chang Xiao

引用次数: 0

Abstract

Reductive deoxygenation of alcohols is particularly challenging because of the high bond dissociation energy of the C-OH bond and the poor leaving ability of the hydroxyl group. Herein we describe a Ph₃P═O-catalyzed reductive deoxygenation of benzyl alcohols with PhSiH₃ under an air atmosphere within 30 min of reaction time. The use of catalytic loading of Ph₃P═O enhances the practicality of this protocol.

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Ph3P═O 催化的醇还原脱氧反应。

醇类的还原脱氧反应尤其具有挑战性，因为 C-OH 键的键解离能很高，而羟基的离去能力很差。在此，我们介绍了在空气气氛下，用 PhSiH3 在 30 分钟反应时间内催化 Ph3P═O 还原脱氧苯甲醇的方法。利用 Ph3P═O 的催化负载提高了该方案的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.

Ph3P═O-Catalyzed Reductive Deoxygenation of Alcohols.

Abstract

Ph₃P═O-Catalyzed Reductive Deoxygenation of Alcohols.