Fine-tuning of proteasome inhibitors through rational pathway engineering

IF 19.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chem Pub Date : 2024-10-10 DOI:10.1016/j.chempr.2024.09.019

Martin Baunach

引用次数: 0

Abstract

The production of tailored biological drugs by genetic engineering represents a significant challenge in the field of natural product chemistry. In this issue of Chem, Bode and co-workers have successfully developed a biosynthetic production platform for novel syrbactin-class proteasome inhibitors by assembling an NRPS/PKS hybrid from four different natural megasynthetases.

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通过合理的途径工程微调蛋白酶体抑制剂

通过基因工程生产定制生物药物是天然产物化学领域的一项重大挑战。在本期《化学》杂志上，Bode 及其合作者通过从四种不同的天然巨合成酶中组装出一种 NRPS/PKS 混合物，成功开发出了一种新型 syrbactin 类蛋白酶体抑制剂的生物合成生产平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chem Environmental Science-Environmental Chemistry

CiteScore

32.40

自引率

1.30%

发文量

281

期刊介绍： Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.