3D structured capillary cell suspensions aided by aqueous two-phase systems†

IF 6.1 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS

Journal of Materials Chemistry B Pub Date : 2024-10-08 DOI:10.1039/D4TB01296H

Amro K. F. Dyab and Vesselin N. Paunov

引用次数: 0

Abstract

We report a facile technique for 3D structuring of living cells by forming capillary cell suspensions based on an aqueous two-phase system (ATPS) of polyethylene glycol (PEG) and dextran (DEX) solutions. We demonstrate the formation of water-in-water (DEX-in-PEG) capillary bridges using concentrated suspensions of yeast cells which show enhanced rheological properties and distinctive 3D patterns. Capillary structured cell suspensions can potentially find applications in novel ways of 3D cell culturing, instant tissue engineering and many biomedical investigations.

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水基两相系统辅助下的三维结构毛细管细胞悬浮液。

我们报告了一种基于聚乙二醇（PEG）和右旋糖酐（DEX）溶液的水性两相体系（ATPS）形成毛细管细胞悬浮液的活细胞三维结构化简便技术。我们利用浓缩的酵母细胞悬浮液证明了水包水（DEX-in-PEG）毛细管桥的形成，这种悬浮液显示出更强的流变特性和独特的三维模式。毛细管结构细胞悬浮液有可能应用于三维细胞培养的新方法、即时组织工程和许多生物医学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.30%

发文量

866

期刊介绍： Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive： Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices