Correlation between forkhead box P3 (rs3761548) gene polymorphism and serum interleukin13 as biomarkers of severity in Egyptian allergic conjunctivitis: a retrospective study.

IF 3.3 Q2 ALLERGY
Frontiers in allergy Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.3389/falgy.2024.1437600
Wesam A Boghdady, Marwa A Khairy, Ali G Ali, Alia A El Shahawy, Eman A Abdelaziz, Aya A El Shahawy, Fatma Z Kamel
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Abstract

Introduction: The genetic variants that alter human Forkhead Box P3 (FOXP3) function may have a part in the establishment of allergic conjunctivitis. Our study aimed to evaluate the FOXP3 polymorphism, serum interleukin13 (IL13) and total immunoglobulin E (IgE) levels in allergic conjunctivitis and assess their role as biomarkers for allergic conjunctivitis risk and severity.

Methods: This study included 52 cases and 52 controls. Blood samples were taken from allergic conjunctivitis patients and controls for total IgE, IL13 measurement and detection of FOXP3 (rs3761548) gene polymorphism.

Results: There was a statistically significant difference between the allergic conjunctivitis group and healthy control group regarding FOXP3 (rs3761548) polymorphism with those have AA genotype are 12 times at risk for allergic conjunctivitis and A allele increases the risk of allergic conjunctivitis by about 4 times. There was statistically significant difference between mild/moderate and severe allergic conjunctivitis regarding FOXP3 (rs3761548) polymorphism with those have AA genotype are 53 times at risk for severe allergic conjunctivitis and A allele increases the risk of severe allergic conjunctivitis by about 6 times. Also, there was a significantly higher value of total IgE IU/ml, IL13 Pg/ml value in severe allergic conjunctivitis compared to moderate/mild allergic conjunctivitis. The best cutoff values of total IgE and serum IL13 for detecting the severity of allergic conjunctivitis were ≥320 IU/ml and ≥40 Pg/ml and the area under the curve were 0.89 and 0.95 respectively.

Conclusion: The research significantly contributes to find correlation of FOXP3 polymorphism, total IgE and IL13 with risk and severity of allergic conjunctivitis which are limited in the literature on the perceived value relevance of FOXP3 polymorphism in allergic conjunctivitis risk and severity.

叉头盒 P3 (rs3761548) 基因多态性与作为埃及过敏性结膜炎严重程度生物标志物的血清白细胞介素 13 之间的相关性:一项回顾性研究。
介绍:改变人类叉头盒 P3(FOXP3)功能的基因变异可能与过敏性结膜炎的形成有关。我们的研究旨在评估过敏性结膜炎患者的 FOXP3 多态性、血清白细胞介素13(IL13)和总免疫球蛋白E(IgE)水平,并评估它们作为过敏性结膜炎风险和严重程度的生物标志物的作用:本研究包括 52 例病例和 52 例对照。从过敏性结膜炎患者和对照组中抽取血液样本,进行总 IgE、IL13 测量和 FOXP3(rs3761548)基因多态性检测:过敏性结膜炎组与健康对照组在 FOXP3(rs3761548)基因多态性方面有显著统计学差异,AA 基因型的人患过敏性结膜炎的风险是健康对照组的 12 倍,而 A 等位基因会使患过敏性结膜炎的风险增加约 4 倍。在 FOXP3(rs3761548)多态性方面,轻度/中度和重度过敏性结膜炎之间的差异有统计学意义,AA 基因型的人患重度过敏性结膜炎的风险是轻度/中度过敏性结膜炎的 53 倍,而 A 等位基因会使患重度过敏性结膜炎的风险增加约 6 倍。此外,与中度/轻度过敏性结膜炎相比,重度过敏性结膜炎患者的总 IgE IU/ml、IL13 Pg/ml 值明显较高。总 IgE 和血清 IL13 检测过敏性结膜炎严重程度的最佳临界值分别为≥320 IU/ml 和≥40 Pg/ml,曲线下面积分别为 0.89 和 0.95:该研究为发现FOXP3多态性、总IgE和IL13与过敏性结膜炎风险和严重程度的相关性做出了重要贡献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.80
自引率
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