Hepatitis E virus infection during pregnancy: Advances in animal models

IF 2.2 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2024-10-02 DOI:10.1016/j.rvsc.2024.105429

Manyu Li , Yan Wang , Wenjun Wan , Zeyu Song , Peilong Wang , Haiwei Zhou

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引用次数: 0

Abstract

Hepatitis E virus (HEV) is one of the major pathogens causing acute viral hepatitis worldwide, which usually causes acute self-limited diseases in general individuals. However, it can lead to high mortality and adverse pregnancy outcomes in pregnant women. Due to the lack of effective and stable cell culture models for HEV, the establishment of suitable animal models for HEV infection during pregnancy is necessary. An electronic search of the relevant database was conducted to identify eligible articles. Main animal models for the study of HEV infection during pregnancy include rabbits, swine, nonhuman primates and Mongolian gerbils. These animal models have been used to study the prevention, treatment and possible mechanisms of HEV infection during pregnancy. Studies using these animal models have investigated the potential pathogenesis of HEV infection during pregnancy. It has been found that immune mechanism (changes in the CD4/CD8 ratio and cytokines), hormonal changes (increase in pregnancy-related hormones) and viral factors (different genotypes and genome structures) can lead to HEV-related adverse pregnancy outcomes in animal models. In this review, we aimed to comprehensively present the characteristics of different animal models and the pathogenesis of HEV-related adverse pregnancy outcomes.

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孕期戊型肝炎病毒感染：动物模型的进展。

戊型肝炎病毒（HEV）是导致全球急性病毒性肝炎的主要病原体之一，通常会导致普通人急性自限性疾病。然而，它可导致孕妇的高死亡率和不良妊娠结局。由于缺乏有效和稳定的 HEV 细胞培养模型，因此有必要建立合适的妊娠期 HEV 感染动物模型。我们对相关数据库进行了电子检索，以确定符合条件的文章。研究孕期 HEV 感染的主要动物模型包括兔子、猪、非人灵长类动物和蒙古沙鼠。这些动物模型被用于研究孕期 HEV 感染的预防、治疗和可能的机制。利用这些动物模型进行的研究调查了妊娠期 HEV 感染的潜在发病机制。研究发现，免疫机制（CD4/CD8 比率和细胞因子的变化）、激素变化（与妊娠相关的激素增加）和病毒因素（不同的基因型和基因组结构）可导致动物模型中与 HEV 相关的不良妊娠结局。本综述旨在全面介绍不同动物模型的特点以及 HEV 相关不良妊娠结局的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.