Performance evaluation of an inorganic optical fibre dosimeter for use in external beam radiotherapy with pulsed beams.

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL
C McDonnell, O McLaughlin, C K McGarry, A R Hounsell, S O'Keeffe, E Lewis, K M Prise
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引用次数: 0

Abstract

Objective. Optical fibre dosimeters (OFDs) offer great promise for real-timein vivodose measurement in radiation-based treatment modalities such as radiotherapy and brachytherapy. This is attributed to their many useful qualities such as high spatial resolution and sensitivity. However, there are several requirements that an optical fibre dosimeter must meet to be acceptable for dose measurement in a specified treatment modality. In this work, the dosimetric performance of a novel optical fibre dosimeter for use in external beam radiotherapy is presented.Approach. The dosimeter was characterised for photon beam energies between 6-15 MV using a Varian TrueBeam Linac at dose rates between 100-2400 MU/min and assessed based on its repeatability, dose dependence, dose rate dependence, energy dependence and dose-per-pulse dependence.Main Results. The results demonstrated excellent short-term repeatability of 0.3%, good linearity in response (R2>0.9997), and minor dose rate dependence between 0.53%-2.49% for all beam qualities investigated. As the scintillator of the OFD is non-water equivalent, Monte-Carlo-TOPAS simulations were used to calculate the absorbed dose energy dependence. A dose-per-pulse dependence was also investigated and compared with dosimetry measurements made with an ionisation chamber and simulated from the treatment planning system. An over-response of 20%was found at the lowest investigated dose-per-pulse, and an under-response of 34%was found at the highest investigated dose-per-pulse. This is believed to be due to an intrinsic energy dependence making this type of OFD unsuitable for external beam radiotherapy dosimetry.Significance. The OFD evaluated in this work was primarily designed for high-dose-rate brachytherapy whereas this study includes the first measurements made in external beam radiotherapy and highlights the challenges of transferability of the dosimeter to a different radiation source.

用于脉冲束外放射治疗的无机光纤剂量计的性能评估。
\目的。光纤剂量计为放疗和近距离放射治疗等基于辐射的治疗模式中的实时活体剂量测量提供了巨大的前景。这要归功于光纤剂量计的许多有用特性,如空间分辨率高和灵敏度高。然而,光纤剂量计要想在特定治疗模式中进行可接受的剂量测量,必须满足多项要求。在这项工作中,介绍了用于体外放射治疗的新型光纤剂量计的剂量测定性能。使用瓦里安 TrueBeam 直列加速器,在剂量率为 100-2400 MU/min 的条件下,对光子束能量为 6-15 MV 的剂量计进行了表征,并根据其可重复性、剂量依赖性、剂量率依赖性、能量依赖性和每脉冲剂量依赖性进行了评估。结果表明,在所研究的所有光束质量中,短期重复性极佳,为 0.3 $/%$,响应线性度良好(R$^{2} >$ 0.9997),剂量率依赖性较小,为 0.53-2.49 $/%$。由于光纤剂量计的闪烁体是非水当量的,因此使用蒙特卡洛-TOPAS 模拟来计算吸收剂量的能量依赖性。此外,还研究了每脉冲剂量的相关性,并与电离室和治疗计划系统模拟的剂量测定结果进行了比较。在研究的最低剂量-脉冲下,发现了 20 $/%$的过响应,而在研究的最高剂量-脉冲下,发现了 34 $/%$的欠响应。这被认为是由于内在的能量依赖性,使得这种光纤剂量计不适合外照射剂量测定。在这项工作中评估的光纤剂量计主要是为高剂量率近距离放射治疗而设计的,而这项研究包括首次在体外射束放射治疗中进行的测量,并强调了将剂量计转移到不同放射源所面临的挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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