Inflammation in Chemotherapy-Induced Cardiotoxicity.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Cardiology Reports Pub Date : 2024-10-08 DOI:10.1007/s11886-024-02131-5

Elizabeth Hutchins, Eric H Yang, Ashley F Stein-Merlob

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引用次数: 0

Abstract

Purpose of review: In this review we describe the role of inflammation in chemotherapy-induced cardiotoxicity with a particular focus on anthracycline-induced cardiomyopathy (AIC). First, we discuss inflammation associated with anthracyclines at a cellular level. Next, we discuss the clinical implications of these inflammatory mechanisms for early detection and cardioprotective strategies in patients undergoing anthracycline treatment.

Recent findings: Key inflammatory pathways identified in AIC include cytokine release, upregulation of the innate immune system via toll-like receptors, and activation of the inflammasome. Emerging evidence suggests a role for inflammatory biomarkers in detecting subclinical AIC. Advanced imaging techniques, such as cardiac PET with novel tracers targeting inflammation, may enhance early detection. Both traditional cardioprotective strategies and novel anti-inflammatory therapies show potential in preventing and treating AIC. Understanding the inflammatory mechanisms involved in AIC provides new opportunities for early detection and targeted cardioprotective strategies in patients undergoing anthracycline treatment and informs our understanding of other forms of chemotherapy-induced cardiotoxicity.

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化疗诱发心脏毒性的炎症反应

综述的目的：在这篇综述中，我们阐述了炎症在化疗诱发的心脏毒性中的作用，尤其关注蒽环类药物诱发的心肌病（AIC）。首先，我们从细胞层面讨论了与蒽环类药物相关的炎症。接下来，我们将讨论这些炎症机制对接受蒽环类药物治疗的患者早期检测和心脏保护策略的临床意义：最近的研究结果：在 AIC 中发现的主要炎症途径包括细胞因子释放、通过收费样受体上调先天性免疫系统以及激活炎性体。新的证据表明，炎症生物标志物在检测亚临床 AIC 中发挥着作用。先进的成像技术，如心脏正电子发射计算机断层扫描（Cardiac PET）和针对炎症的新型示踪剂，可增强早期检测的效果。传统的心脏保护策略和新型抗炎疗法都显示出预防和治疗 AIC 的潜力。了解 AIC 所涉及的炎症机制为蒽环类药物治疗患者的早期检测和有针对性的心脏保护策略提供了新的机会，也有助于我们了解其他形式的化疗诱发的心脏毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Cardiology Reports CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

6.20

自引率

2.70%

发文量

209

期刊介绍： The aim of this journal is to provide timely perspectives from experts on current advances in cardiovascular medicine. We also seek to provide reviews that highlight the most important recently published papers selected from the wealth of available cardiovascular literature. We accomplish this aim by appointing key authorities in major subject areas across the discipline. Section editors select topics to be reviewed by leading experts who emphasize recent developments and highlight important papers published over the past year. An Editorial Board of internationally diverse members suggests topics of special interest to their country/region and ensures that topics are current and include emerging research. We also provide commentaries from well-known figures in the field.