Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab Countries.

IF 2.1 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current drug metabolism Pub Date : 2024-10-04 DOI:10.2174/0113892002323910240924145310

Laith Al Eitan, Iliya Yacoub Khair, Saif Alahmad

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Abstract

Drug metabolizing enzymes play a crucial role in the pharmacokinetics and pharmacodynamics of therapeutic drugs, influencing their efficacy and safety. This review explores the impact of genetic polymorphisms in drug-metabolizing genes on drug response within Arab populations. We examine the genetic diversity specific to Arab countries, focusing on the variations in key drug-metabolizing enzymes such as CYP450, GST, and UGT families. The review highlights recent research on polymorphisms in these genes and their implications for drug metabolism, including variations in allele frequencies and their effects on therapeutic outcomes. Additionally, the paper discusses how these genetic variations contribute to the variability in drug response and adverse drug reactions among individuals in Arab populations. By synthesizing current findings, this review aims to provide a comprehensive understanding of the pharmacogenetic landscape in Arab countries and offer insights into personalized medicine approaches tailored to genetic profiles. The findings underscore the importance of incorporating pharmacogenetic data into clinical practice to enhance drug efficacy and minimize adverse effects, ultimately paving the way for more effective and individualized treatment strategies in the region.

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药物代谢酶：阿拉伯国家药物基因动态最新研究独家指南》。

药物代谢酶在治疗药物的药代动力学和药效学中起着至关重要的作用，影响着药物的疗效和安全性。本综述探讨了阿拉伯人群中药物代谢基因的遗传多态性对药物反应的影响。我们研究了阿拉伯国家特有的遗传多样性，重点是 CYP450、GST 和 UGT 家族等关键药物代谢酶的变异。综述重点介绍了这些基因多态性的最新研究及其对药物代谢的影响，包括等位基因频率的变化及其对治疗效果的影响。此外，论文还讨论了这些基因变异如何导致阿拉伯人群中个体间药物反应和药物不良反应的差异。通过综合目前的研究结果，本综述旨在提供对阿拉伯国家药物遗传学状况的全面了解，并为针对遗传特征的个性化医疗方法提供真知灼见。研究结果强调了将药物基因数据纳入临床实践的重要性，以提高药物疗效并最大限度地减少不良反应，最终为该地区制定更有效的个性化治疗策略铺平道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug metabolism 医学-生化与分子生物学

CiteScore

4.30

自引率

4.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism. More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.