Non-Tuberculous Mycobacterial Pulmonary Disease with Detection of Mycobacterium Tuberculosis in Pleural Fluid.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2024-10-01 DOI:10.7754/Clin.Lab.2024.240531

Ling Zhang, Si Y Sun, Xue X Yao, Ai S Fu, Yan L Ge

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引用次数: 0

Abstract

Background: Tuberculous pleurisy (TP) is one of the most common types of extrapulmonary tuberculosis, often secondary to tuberculosis (TB). Clinical and imaging manifestations of non-tuberculous mycobacterial pulmonary diseases (NTM-PD) are usually similar to those of tuberculosis. Because of their similarity and the high incidence of tuberculosis, non-tuberculous mycobacterial infections are often overlooked for a long time. Especially in people without immunodeficiency.

Methods: Mycobacterium tuberculosis (MTB) in pleural effusion was found by metagenomic next-generation sequencing (mNGS). During anti-tuberculosis treatment, mNGS of lung tissue by ultrasound-guided percutaneous lung puncture revealed that this patient had combined NTM-PD.

Results: Mycobacterium chelonae (M. chelonae) was detected by mNGS, and after anti-NTM treatment, the patient's chest CT showed that the inflammation was absorbed more than before, and the patient's symptoms improved.

Conclusions: When TB is poorly treated with standardized anti-tuberculosis therapy, comorbid non-tuberculous mycobacterial infections may be considered, and mNGS may complement traditional pathogenetic testing.

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胸腔积液中检测出结核分枝杆菌的非结核分枝杆菌肺病

背景：结核性胸膜炎（TP）是肺外结核病最常见的类型之一，通常继发于肺结核（TB）。非结核分枝杆菌肺病（NTM-PD）的临床和影像学表现通常与肺结核相似。由于其相似性和结核病的高发病率，非结核分枝杆菌感染往往长期被忽视。尤其是在没有免疫缺陷的人群中：方法：通过元基因组下一代测序（mNGS）发现胸腔积液中的结核分枝杆菌（MTB）。在抗结核治疗期间，通过超声引导下经皮肺穿刺肺组织的 mNGS 发现该患者合并 NTM-PD：结果：通过 mNGS 检测出卡氏分枝杆菌（M. chelonae），经过抗 NTM 治疗后，患者的胸部 CT 显示炎症比之前吸收得更多，患者的症状也有所改善：结论：当结核病经规范抗结核治疗效果不佳时，可考虑合并非结核分枝杆菌感染，mNGS 可作为传统病原学检测的补充。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.