Bacteria renew an OLD protein to cleave host tRNAs and block phage translation

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-10-09 DOI:10.1016/j.chom.2024.09.006

Kyle D. Gibbs, Michele LeRoux

引用次数: 0

Abstract

Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of papers in Nature reveal via structural and functional assays how the PARIS defense system, a recently discovered toxin-antitoxin system, senses phage-associated molecular patterns (PhAMPs), thereby activating an endonuclease toxin that cleaves tRNA to block phage replication.

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细菌更新一种古老的蛋白质，以裂解宿主 tRNA 并阻止噬菌体翻译

抗噬菌体防御系统必须迅速感知并应对各种病毒。最近发表在《自然》（Nature）上的两篇论文通过结构和功能测试揭示了 PARIS 防御系统（一种最近发现的毒素-抗毒素系统）如何感知噬菌体相关分子模式（PhAMPs），从而激活内切酶毒素，裂解 tRNA 以阻止噬菌体复制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.