Cell death: Revisiting the roads to ruin

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2024-10-07 DOI:10.1016/j.devcel.2024.08.008

Douglas R. Green

引用次数: 0

Abstract

A paradigm shift in the study of cell death is currently occurring: whereas previously we had always considered that there were “points of no return” in any cell death pathway, we now realize that in many types of active, regulated cell death, this is not the case. We are also learning that cells that “almost die,” but nevertheless survive, can transiently take on an altered state, with potential implications for understanding cancer therapies and relapse. In this perspective, we parse the many forms of cell death by analogy to suicide, sabotage, and murder, and consider how cells that might be “instructed” to engage a cell death pathway might nevertheless survive.

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细胞死亡重温毁灭之路

目前，细胞死亡研究的范式正在发生转变：以前我们一直认为，任何细胞死亡途径都有 "不归点"，而现在我们认识到，在许多类型的活跃、受调控的细胞死亡中，情况并非如此。我们还了解到，"几乎死亡 "但仍存活下来的细胞可以短暂地改变状态，这对理解癌症疗法和复发具有潜在影响。在这一视角中，我们通过类比自杀、破坏和谋杀来解析细胞死亡的多种形式，并思考细胞如何可能在 "指示 "下参与细胞死亡途径后仍然存活下来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.