How safe and effective is irradiating radiation-induced meningiomas? Single-center experience in primary and salvage Gamma-Knife Radiosurgery, systematic review, and metanalysis of current evidence on the topic

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2024-10-05 DOI:10.1016/j.critrevonc.2024.104526

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引用次数: 0

Abstract

This is a single-center experience and metanalysis of the safety and efficacy measures of Gamma-knife stereotactic radiosurgery (SRS-GK) for radiation-induced meningiomas (RIMs). This study comprised a single-center analysis of SRS-GK for RIMs at IRCCS San Raffaele Hospital, Milan, Italy, and a systematic literature review and meta-analysis to address the actuarial local control (LC), distant control (DC), progression-free survival (PFS), and toxicity. The original series comprised 13 patients harboring 30 RIMs. Partial response was observed in 26 %, stability in 52 %, and progression in 22 %. The 5-year LC and DC rates were 71 % and 67 %. One patient developed radionecrosis, and an additional 2 presented edema. Metanalysis comprised 4 papers and data from the original series, comprising 146 patients and 308 RIMs. The 5-year LC was 84 %, the DC 67 %, and radionecrosis in 1.4 %. SRS-GK has an efficacy profile falling between that observed for radiologically suspected sporadic meningiomas and confirmed higher-grade lesions.

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照射放射诱发脑膜瘤的安全性和有效性如何？伽玛刀放射外科手术的单中心初治和抢救经验、系统性回顾以及当前相关证据的荟萃分析。

这是一项关于伽马刀立体定向放射外科手术（SRS-GK）治疗辐射诱发脑膜瘤（RIMs）的安全性和有效性的单中心经验和荟萃分析。这项研究包括意大利米兰IRCCS圣拉斐尔医院对SRS-GK治疗脑膜瘤的单中心分析，以及针对精算局部控制（LC）、远处控制（DC）、无进展生存期（PFS）和毒性的系统性文献回顾和荟萃分析。最初的系列研究包括13名患者，共携带30个RIMs。26%的患者出现部分反应，52%的患者病情稳定，22%的患者病情恶化。5年LC和DC率分别为71%和67%。一名患者出现放射性坏死，另外两名患者出现水肿。Metanalysis 包括 4 篇论文和原始系列的数据，共有 146 名患者和 308 个 RIM。5年生存率为84%，DC为67%，放射性坏死为1.4%。SRS-GK 的疗效介于放射学疑似散发性脑膜瘤和确诊的高级别病变之间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.