Associations between peripheral whole blood cell counts derived indexes and cancer prognosis: An umbrella review of meta-analyses of cohort studies

IF 5.5 2区医学 Q1 HEMATOLOGY

Critical reviews in oncology/hematology Pub Date : 2024-10-05 DOI:10.1016/j.critrevonc.2024.104525

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引用次数: 0

Abstract

Meta-analyses have reported conflicting data on the whole blood cell count (WBCC) derived indexes (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], and lymphocyte-to-monocyte ratio [LMR]) and cancer prognosis. However, the strength and quality of this evidence has not been quantified in aggregate. To grade the evidence from published meta-analyses of cohort studies that investigated the associations between NLR, PLR, and LMR and cancer prognosis. A total of 694 associations from 224 articles were included. And 219 (97.8%) articles rated as moderate-to-high quality according to AMSTAR. There were four associations supported by convincing evidence. Meanwhile, 165 and 164 associations were supported by highly suggestive and suggestive evidence, respectively. In this umbrella review, we summarized the existing evidence on the WBCC-derived indexes and cancer prognosis. Due to the direction of effect sizes is not completely consistent between studies, further research is needed to assess causality and provide firm evidence.

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外周全血细胞计数衍生指标与癌症预后之间的关系：队列研究荟萃分析综述。

关于全血细胞计数（WBCC）得出的指标（中性粒细胞与淋巴细胞比值[NLR]、血小板与淋巴细胞比值[PLR]和淋巴细胞与单核细胞比值[LMR]）和癌症预后，有相互矛盾的数据报告。然而，这些证据的强度和质量尚未得到综合量化。对已发表的研究 NLR、PLR 和 LMR 与癌症预后关系的队列研究的荟萃分析证据进行分级。共纳入了 224 篇文章中的 694 项关联。其中219篇文章（97.8%）被AMSTAR评为中高质量。有四项关联得到了令人信服的证据支持。同时，分别有 165 条和 164 条关联得到了高度提示性和提示性证据的支持。在这篇综述中，我们总结了关于WBCC衍生指标和癌症预后的现有证据。由于不同研究之间效应大小的方向并不完全一致，因此需要进一步的研究来评估因果关系并提供确凿证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical reviews in oncology/hematology 医学-血液学

CiteScore

11.00

自引率

3.20%

发文量

213

审稿时长

55 days

期刊介绍： Critical Reviews in Oncology/Hematology publishes scholarly, critical reviews in all fields of oncology and hematology written by experts from around the world. Critical Reviews in Oncology/Hematology is the Official Journal of the European School of Oncology (ESO) and the International Society of Liquid Biopsy.