Aberrant nuclei with amplified DNA in cancer.

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2024-10-05 DOI:10.1016/j.trecan.2024.09.005

Venkata Narasimha Kadali, Ofer Shoshani

引用次数: 0

Abstract

Gene amplification in the form of extrachromosomal DNA (ecDNA) or intrachromosomal homogenous staining regions (HSRs) is an emerging hallmark in cancer. Recent studies implicate abnormal nuclear structures in the biogenesis and evolution of amplified DNA. Here, we discuss how the interplay between aberrant nuclei and gene amplification drives cancer therapy resistance and metastasis.

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癌症中DNA扩增的异常细胞核。

染色体外 DNA（ecDNA）或染色体内同源染色区（HSR）形式的基因扩增是癌症的一个新特征。最近的研究表明，核结构异常与扩增 DNA 的生物发生和进化有关。在此，我们将讨论异常细胞核与基因扩增之间的相互作用是如何驱动癌症耐药性和转移的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.