The PIK3CA gene and its pivotal role in tumor tropism of triple-negative breast cancer

IF 5 2区医学 Q2 Medicine

Translational Oncology Pub Date : 2024-10-05 DOI:10.1016/j.tranon.2024.102140

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引用次数: 0

Abstract

The PIK3CA gene is a linchpin in the intricate molecular network governing triple-negative breast cancer (TNBC) tumor tropism, serving as a focal point for understanding this aggressive disease. Anchored within the PI3K/AKT/mTOR signaling axis, PIK3CA mutations exert substantial influence, driving cellular processes that highlight the unique biology of TNBC. This review meticulously highlights the association between PIK3CA mutations and distinct TNBC subtypes, elucidating the gene's multifaceted contributions to tumor tropism. Molecular dissection reveals how PIK3CA mutations dynamically modulate chemokine responses, growth factor signaling, and extracellular matrix interactions, orchestrating the complex migratory behaviour characteristic of TNBC cells. A detailed exploration of PIK3CA-targeted strategies in the therapeutic arena is presented, outlining the current landscape of clinical trials and precision medicine approaches. As the scientific narrative converges, this review underscores the critical role of PIK3CA in shaping the molecular intricacies of TNBC tumor tropism and illuminates pathways toward tailored interventions, promising a paradigm shift in the clinical management of TNBC.

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PIK3CA 基因及其在三阴性乳腺癌肿瘤滋养过程中的关键作用。

PIK3CA 基因是支配三阴性乳腺癌（TNBC）肿瘤趋向的复杂分子网络中的关键，是了解这种侵袭性疾病的焦点。PIK3CA 基因突变锚定在 PI3K/AKT/mTOR 信号转导轴上，对 TNBC 的细胞过程产生了重大影响，凸显了 TNBC 独特的生物学特性。这篇综述细致地强调了PIK3CA突变与不同TNBC亚型之间的关联，阐明了该基因对肿瘤滋养的多方面贡献。分子剖析揭示了PIK3CA突变如何动态调节趋化因子反应、生长因子信号转导和细胞外基质相互作用，从而协调TNBC细胞特有的复杂迁移行为。本文详细探讨了治疗领域的 PIK3CA 靶向策略，概述了当前的临床试验和精准医疗方法。随着科学叙事的汇聚，这篇综述强调了 PIK3CA 在形成 TNBC 肿瘤向性错综复杂的分子过程中的关键作用，并阐明了实现定制干预的途径，有望实现 TNBC 临床管理模式的转变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Translational Oncology ONCOLOGY-

CiteScore

8.40

自引率

2.00%

发文量

314

审稿时长

54 days

期刊介绍： Translational Oncology publishes the results of novel research investigations which bridge the laboratory and clinical settings including risk assessment, cellular and molecular characterization, prevention, detection, diagnosis and treatment of human cancers with the overall goal of improving the clinical care of oncology patients. Translational Oncology will publish laboratory studies of novel therapeutic interventions as well as clinical trials which evaluate new treatment paradigms for cancer. Peer reviewed manuscript types include Original Reports, Reviews and Editorials.