Mapping brain activity and neurotransmitters pre-cigarette smoking evolution: A study of male subjects

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2024-10-02 DOI:10.1016/j.jpsychires.2024.09.051

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引用次数: 0

Abstract

Background

The impact of tobacco smoking on global health persists and it is essential to understand the progression of addiction and the involvement of neurotransmitters.

Methods

This study assessed 47 participants with tobacco use disorder (TUD) categorized based on changes in Fagerström Test for Nicotine Dependence (FTND) scores over 6 years: progressive TUD (pTUD), regressive TUD (rTUD), and stable TUD (sTUD). Additionally, 35 healthy controls were included. Resting-state functional magnetic resonance imaging was used to evaluate brain regional homogeneity (ReHo) and correlations with neurotransmitter distributions using JuSpace.

Results

Significant differences in ReHo were observed among pTUD, rTUD, sTUD, and controls. After strict Bonferroni correction, rTUD exhibited increased ReHo in the dorsolateral superior frontal gyrus compared to sTUD (p < 0.001) and controls (p < 0.001). Both pTUD (p < 0.001) and rTUD (p < 0.001) showed decreased ReHo in the superior temporal gyrus compared to sTUD. sTUD had increased ReHo in the supramarginal gyrus compared to all other groups (p < 0.001, p < 0.001, p = 0.002, separately). The strongest association, which survived rigorous Bonferroni correction, was between the ReHo changes in rTUD compared to sTUD and neurotransmitter distribution. This includes 5-hydroxytryptamine receptor 2A (p = 0.001), gamma-aminobutyric acid type A receptor (p < 0.001), norepinephrine transporter (p < 0.001), and N-Methyl-D-Aspartate (p = 0.002).

Conclusions

This study provides insights into how smoking behaviors correlate with alterations in brain activity and neurotransmitter function. By elucidating these neural links to tobacco use disorder progression, our findings contribute to a deeper understanding of smoking's neurological impact and potentially inform more targeted therapeutic strategies.

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绘制吸烟演变前的大脑活动和神经递质图：男性受试者研究

背景：吸烟对全球健康的影响依然存在，因此了解烟草成瘾的发展过程以及神经递质的参与至关重要：本研究评估了47名患有烟草使用障碍（TUD）的参与者，根据其6年来在法格斯特伦尼古丁依赖测试（FTND）中的得分变化将其分为：进行性TUD（pTUD）、退行性TUD（rTUD）和稳定型TUD（sTUD）。此外，还纳入了 35 名健康对照者。利用静息态功能磁共振成像评估大脑区域同质性（ReHo），并使用 JuSpace 评估与神经递质分布的相关性：在 pTUD、rTUD、sTUD 和对照组之间观察到 ReHo 存在显著差异。经过严格的 Bonferroni 校正后，与 sTUD 相比，rTUD 在额上回背外侧的 ReHo 有所增加（p 结论：rTUD 在额上回背外侧的 ReHo 有所增加：本研究有助于深入了解吸烟行为如何与大脑活动和神经递质功能的改变相关联。通过阐明这些与烟草使用障碍进展的神经联系，我们的研究结果有助于加深对吸烟对神经系统影响的理解，并有可能为更有针对性的治疗策略提供依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;