Clinical implications of CT-detected ascites in gastric cancer: association with peritoneal metastasis and systemic inflammatory response.

IF 4.1 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Insights into Imaging Pub Date : 2024-10-07 DOI:10.1186/s13244-024-01818-1

Mengying Xu, Dan Liu, Le Wang, Shuangshuang Sun, Song Liu, Zhengyang Zhou

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引用次数: 0

Abstract

Objectives: This study aimed to evaluate the diagnostic significance of computed tomography (CT) detected ascites in gastric cancer (GC) with peritoneal metastasis (PM) and investigate its association with systemic inflammatory response.

Methods: This retrospective study included 111 GCs with ascites (PM: n = 51; No PM: n = 60). Systemic inflammatory indexes, tumor markers, and the CT-assessed characteristics of ascites were collected. The differences in parameters between the two groups were analyzed. Diagnostic performance was obtained by receiver operating characteristic curve analysis. The association between the volume of ascites and clinical characteristics was evaluated with correlation analysis.

Results: In this study, over half of GCs with ascites were not involved with PM. The systemic immune-inflammation index (SII), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), five tumor markers, and the characteristics of ascites showed significant differences between the two groups (all p < 0.05). Among them, SII, NLR, PLR, and the volume of ascites achieved the areas under the curve of 0.700, 0.698, 0.704, and 0.903, respectively. Moreover, the volumes of ascites showed positive correlations with SII, NLR, and PLR in GCs with PM, and the volumes of ascites detected in the upper abdomen were more strongly correlated with CA125 level (all p < 0.05).

Conclusion: Many GCs with CT-detected ascites did not occur with synchronous PM. The presence of upper abdominal ascites had certain clinical significance for diagnosing PM in GCs. Systemic inflammatory indexes were elevated and positively correlated with the volume of ascites in GCs with PM, which might suggest the enhanced systemic inflammatory response.

Critical relevance statement: CT-detected ascites in the upper abdomen played an indicative role in identifying synchronous PM in GCs, and the systemic inflammatory response was enhanced in GCs with PM, which might be helpful for clinical evaluation.

Key points: Many GCs with CT-detected ascites did not occur with synchronous PM. CT-detected ascites in the upper abdomen help in identifying PM in GCs. GCs with PM showed elevated systemic inflammatory indexes and enhanced systemic inflammatory response.

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CT 检测到的胃癌腹水的临床意义：与腹膜转移和全身炎症反应有关。

研究目的本研究旨在评估计算机断层扫描（CT）检测到的腹水对伴有腹膜转移（PM）的胃癌（GC）的诊断意义，并研究其与全身炎症反应的关系：这项回顾性研究纳入了111例有腹水的胃癌患者（有腹水：51例；无腹水：60例）。收集了全身炎症指标、肿瘤标志物和 CT 评估的腹水特征。分析了两组之间参数的差异。通过接收者操作特征曲线分析得出诊断结果。通过相关性分析评估了腹水体积与临床特征之间的关联：结果：在这项研究中，半数以上有腹水的 GCs 未伴有 PM。两组患者的全身免疫炎症指数（SII）、中性粒细胞-淋巴细胞比值（NLR）、血小板-淋巴细胞比值（PLR）、五种肿瘤标志物以及腹水特征均显示出显著差异（均为 p 结论：许多 CT 检测出腹水的 GC 患者都患有肿瘤：许多 CT 检测到腹水的 GC 并不伴有同步 PM。上腹部腹水的存在对诊断 GCs 中的 PM 有一定的临床意义。在有 PM 的 GC 中，全身炎症指标升高且与腹水量呈正相关，这可能表明全身炎症反应增强：CT检测到的上腹部腹水在鉴别GCs同步性PM中起着指示性作用，且患有PM的GCs全身炎症反应增强，这可能有助于临床评估：要点：许多 CT 检测到腹水的 GC 并不伴有同步 PM。CT检测到的上腹部腹水有助于鉴别GCs中的PM。有PM的GC患者全身炎症指数升高，全身炎症反应增强。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

7.30

自引率

4.30%

发文量

182

审稿时长

13 weeks

期刊介绍： Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.