When Chinese patients with plasma cell disorders encountered the nationwide Omicron outbreak (December 2022): a real-world multicenter and multiregional study.

IF 2 4区 医学 Q3 HEMATOLOGY
Hematology Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI:10.1080/16078454.2024.2411741
Xincheng Jiang, Xiaoyan Han, Fengyan Jin, Gang An, Jian Hou, Jingsong He, Qingming Wang, Wenjun Wu, Yi Zhao, Songfu Jiang, Shuchan Li, Zhenshu Xu, Gaofeng Zheng, Yang Yang, Qingxiao Chen, Donghua He, Yi Li, Zhen Cai
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引用次数: 0

Abstract

Objectives: This study aims to assess the impact of the nationwide Omicron outbreak in December 2022 on Chinese patients with plasma cell disorders (PCD), focusing on the clinical characteristics of PCD patients with COVID-19 and the risk factors contributing to adverse clinical courses (severity and hospitalization) and outcomes.

Methods: A multicenter retrospective study was performed from December 1, 2022, to January 19, 2023. The study population includes 404 PCD patients, divided into a COVID-19 group (n = 342) and an uninfected group (n = 62).

Results: The frequency of COVID-19 infection was 84.7% (342/404), and 16.4% (56/342) were severe COVID-19. Among the 277 patients with complete follow-up, 2 deaths (0.7%) were reported, while 231 (83.4%) recovered from COVID-19. Age > 65 (P = 0.02) and prior anti-CD38 monoclonal antibody (mAb) treatment within six months (P = 0.03) were independent risk factors for severe infection. Additionally, previous chimeric antigen receptor T-cell (CAR-T) therapy within six months was correlated with a higher risk of hospitalization (P = 0.04) and prolonged recovery time (P = 0.03). No significant protective effect of vaccination on infection or severe infection was observed (P > 0.05).

Conclusions: The latest Omicron outbreak results in higher rates of severe infection and mortality in PCD patients compared with the general population in China, highlighting the need to protect this vulnerable population during the pandemic. Recent use of anti-CD38 mAb and CAR-T therapy are associated with poorer clinical courses and outcomes of PCD patients with COVID-19.

当中国浆细胞疾病患者遭遇全国范围的 "欧米茄 "疫情爆发(2022 年 12 月)时:一项多中心、多区域的真实世界研究。
研究目的本研究旨在评估2022年12月在全国范围内爆发的Omicron疫情对中国浆细胞疾病(PCD)患者的影响,重点关注COVID-19型PCD患者的临床特征以及导致不良临床过程(严重程度和住院治疗)和结局的风险因素:多中心回顾性研究于2022年12月1日至2023年1月19日进行。研究对象包括404名PCD患者,分为COVID-19感染组(342人)和未感染组(62人):结果:COVID-19感染率为84.7%(342/404),其中16.4%(56/342)为重度COVID-19感染。在完成随访的 277 名患者中,有 2 人死亡(0.7%),231 人(83.4%)从 COVID-19 中康复。年龄大于 65 岁(P = 0.02)和曾在 6 个月内接受过抗 CD38 单克隆抗体 (mAb) 治疗(P = 0.03)是导致严重感染的独立风险因素。此外,6个月内接受过嵌合抗原受体T细胞(CAR-T)治疗与较高的住院风险(P = 0.04)和较长的恢复时间(P = 0.03)相关。接种疫苗对感染或严重感染没有明显的保护作用(P > 0.05):结论:与中国普通人群相比,最近一次奥米克龙疫情导致 PCD 患者的严重感染率和死亡率较高,这凸显了在大流行期间保护这一易感人群的必要性。最近使用的抗 CD38 mAb 和 CAR-T 疗法与 COVID-19 PCD 患者较差的临床病程和预后有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Hematology
Hematology 医学-血液学
CiteScore
2.60
自引率
5.30%
发文量
140
审稿时长
3 months
期刊介绍: Hematology is an international journal publishing original and review articles in the field of general hematology, including oncology, pathology, biology, clinical research and epidemiology. Of the fixed sections, annotations are accepted on any general or scientific field: technical annotations covering current laboratory practice in general hematology, blood transfusion and clinical trials, and current clinical practice reviews the consensus driven areas of care and management.
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