The prognostic value of skeletal muscle mass and density in breast cancer: a systematic review and meta-analysis.

IF 3 4区医学 Q2 ONCOLOGY

Future oncology Pub Date : 2024-10-07 DOI:10.1080/14796694.2024.2402215

Huijun Deng, Leiqiong Wang, Yuxuan Li

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引用次数: 0

Abstract

Aim: The effect of skeletal muscle mass and density on the long-term survival outcome of breast cancer patients is unclear.Materials & methods: Systematically searched all articles in PubMed, Web of science, Springerlink, EMBASE and Wiley databases that studied the association between skeletal muscle and survival outcomes of breast cancer by 25 September 2023. The hazard ratios and confidence intervals of the multiple factor analysis results controlling for confounding variables in the study were collected and analyzed using STATA 14.0 software.Results: This meta-analysis included a total of 13 studies, with a median age of 48.2 years. Meta results showed that the survival (hazard ratio [HR]: 0.98, 95% CI: 0.89-1.08) and recurrence (HR: 0.96, 95% CI: 0.92-1.00) outcomes of breast cancer patients with sarcopenia were not significantly affected compared with those without sarcopenia. No significant heterogeneity or publication bias was observed in the study.Conclusion: The conclusion that skeletal muscle is regarded as a useful factor that can guide and optimize the prognosis of breast cancer patients is uncertain, or the result is very weak. Considering the impact of research quality and confounding factors, prospective studies are needed in the future to further demonstrate.PROSPERO identifier: CRD42023463480 (www.crd.york.ac.uk/prospero).

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乳腺癌患者骨骼肌质量和密度的预后价值：系统回顾和荟萃分析。

目的：骨骼肌质量和密度对乳腺癌患者长期生存结果的影响尚不明确：系统检索了截至2023年9月25日PubMed、Web of science、Springerlink、EMBASE和Wiley数据库中所有研究骨骼肌与乳腺癌生存结果相关性的文章。使用 STATA 14.0 软件收集并分析了研究中控制混杂变量的多因素分析结果的危险比和置信区间：该荟萃分析共纳入 13 项研究，中位年龄为 48.2 岁。荟萃结果显示，与无肌肉疏松症的乳腺癌患者相比，有肌肉疏松症的乳腺癌患者的生存率（危险比 [HR]：0.98，95% CI：0.89-1.08）和复发率（HR：0.96，95% CI：0.92-1.00）并无明显影响。研究未发现明显的异质性或发表偏倚：认为骨骼肌是指导和优化乳腺癌患者预后的有用因素这一结论并不确定，或者说结果非常微弱。考虑到研究质量和混杂因素的影响，未来需要进行前瞻性研究来进一步证明：CRD42023463480 (www.crd.york.ac.uk/prospero)。

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来源期刊

Future oncology ONCOLOGY-

CiteScore

5.40

自引率

3.00%

发文量

335

审稿时长

4-8 weeks

期刊介绍： Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.