Gamma-aminobutyric acid in the honey bee mushroom bodies — is inhibition the wellspring of plasticity?

IF 5.8 1区农林科学 Q1 BIOLOGY

Current opinion in insect science Pub Date : 2024-10-05 DOI:10.1016/j.cois.2024.101278

Susan E Fahrbach

引用次数: 0

Abstract

Structural plasticity is the hallmark of the protocerebral mushroom bodies of adult insects. This plasticity is especially well studied in social hymenopterans. In adult worker honey bees, phenomena such as increased neuropil volume, increased dendritic branching, and changes in the details of synaptic microcircuitry are associated with both the onset of foraging and the accumulation of foraging experience. Prior models of the drivers of these changes have focused on differences between the sensory environment of the hive and the world outside the hive, leading to enhanced excitatory (cholinergic) inputs to the intrinsic neurons of the mushroom bodies (Kenyon cells). This article proposes experimental and bioinformatics-based approaches for the exploration of a role for changes in the inhibitory (GABAergic) innervation of the mushroom bodies as a driver of sensitive periods for structural plasticity in the honey bee brain.

查看原文本刊更多论文

蜜蜂蘑菇体内的 GABA - 抑制是可塑性的源泉吗？

结构可塑性是成虫原脑蘑菇体的标志。这种可塑性在社会性膜翅目昆虫中的研究尤为深入。在成年工蜂中，神经鞘体积的增加、树突分枝的增加以及突触微电路细节的变化等现象都与开始觅食和觅食经验的积累有关。先前关于这些变化驱动因素的模型主要集中在蜂巢感官环境与蜂巢外世界之间的差异，这种差异导致蘑菇伞体固有神经元（凯尼恩细胞）的兴奋性（胆碱能）输入增强。本文提出了基于实验和生物信息学的方法，以探索蘑菇体抑制性（GABA能）神经支配的变化作为蜜蜂大脑结构可塑性敏感期驱动因素的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.