Lipid metabolism: Novel approaches for managing idiopathic epilepsy

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Neuropeptides Pub Date : 2024-09-29 DOI:10.1016/j.npep.2024.102475

Chao Wang, Jinxia Zhai, Xuemei Zhou, Yongjun Chen

引用次数: 0

Abstract

Epilepsy is a common neurological condition characterized by abnormal neuronal activity, often leading to cellular damage and death. There is evidence to suggest that lipid imbalances resulting in cellular death play a key role in the development of epilepsy, including changes in triglycerides, cholesterol, sphingolipids, phospholipids, lipid droplets, and bile acids (BAs). Disrupted lipid metabolism acts as a crucial pathological mechanism in epilepsy, potentially linked to processes such as cellular ferroptosis, lipophagy, and immune modulation of gut microbiota (thus influencing the gut-brain axis). Understanding these mechanisms could open up new avenues for epilepsy treatment. This study investigates the association between disturbances in lipid metabolism and the onset of epilepsy.

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脂质代谢：治疗特发性癫痫的新方法。

癫痫是一种常见的神经系统疾病，其特点是神经元活动异常，常常导致细胞损伤和死亡。有证据表明，导致细胞死亡的脂质失衡在癫痫发病中起着关键作用，包括甘油三酯、胆固醇、鞘脂、磷脂、脂滴和胆汁酸（BAs）的变化。脂质代谢紊乱是癫痫的一个重要病理机制，可能与细胞铁凋亡、脂质吞噬和肠道微生物群的免疫调节（从而影响肠道-大脑轴）等过程有关。了解这些机制可为癫痫治疗开辟新途径。本研究探讨了脂质代谢紊乱与癫痫发病之间的关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.