Regulation of HNRNP family by post-translational modifications in cancer.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2024-10-04 DOI:10.1038/s41420-024-02198-7

Bohao Li, Mingxin Wen, Fei Gao, Yunshan Wang, Guangwei Wei, Yangmiao Duan

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Abstract

Heterogeneous nuclear ribonucleoproteins (HNRNPs) represent a large family of RNA-binding proteins consisting of more than 20 members and have attracted great attention with their distinctive roles in cancer progression by regulating RNA splicing, transcription, and translation. Nevertheless, the cancer-specific modulation of HNRNPs has not been fully elucidated. The research of LC-MS/MS technology has documented that HNRNPs were widely and significantly targeted by different post-translational modifications (PTMs), which have emerged as core regulators in shaping protein functions and are involved in multiple physiological processes. Accumulating studies have highlighted that several PTMs are involved in the mechanisms of HNRNPs regulation in cancer and may be suitable therapeutic targets. In this review, we summarize the existing evidence describing how PTMs modulate HNRNPs functions on gene regulation and the involvement of their dysregulation in cancer, which will help shed insights on their clinical impacts as well as possible therapeutic tools targeting PTMs on HNRNPs.

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癌症中翻译后修饰对 HNRNP 家族的调控。

异质性核核糖核蛋白（HNRNPs）是一个由 20 多个成员组成的 RNA 结合蛋白大家族，通过调控 RNA 剪接、转录和翻译，在癌症进展中发挥着独特的作用，因而备受关注。然而，HNRNPs 的癌症特异性调控尚未完全阐明。LC-MS/MS 技术的研究表明，HNRNPs 被不同的翻译后修饰（PTM）广泛而显著地靶向，这些修饰已成为塑造蛋白质功能的核心调控因子，并参与多种生理过程。越来越多的研究强调，一些 PTMs 参与了 HNRNPs 在癌症中的调控机制，并可能成为合适的治疗靶点。在这篇综述中，我们总结了现有的证据，描述了 PTMs 如何调节 HNRNPs 在基因调控中的功能以及它们在癌症中的失调，这将有助于深入了解它们的临床影响以及针对 HNRNPs 上的 PTMs 的可能治疗工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.