{"title":"Supramolecular Palladium Complexes Based on Guanidinium Pillar[5]arene for Cancer Therapy","authors":"Yafei Wen, Xiaojiao Di, Zelong Chen, Xuxu Zhang, Zhichao Pei, Yuxin Pei","doi":"10.1039/d4cc04312j","DOIUrl":null,"url":null,"abstract":"The supramolecular palladium complex G-Pd, formed via self-assembly of Pd-complex of guanidinium pillar[5]arene with Pd²⁺, was used to encapsulate doxorubicin to G-Pd@DOX. The nanoparticles exhibit responsiveness to glutathione, controlled drug release, ability to damage mitochondria, and potent anticancer activity while maintaining low toxicity towards normal cells. This work provides a good example for the application of pillararene-based palladium complexes in cancer therapy, and is significant for discovery of new medicine from supramolecular coordination complexes.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d4cc04312j","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The supramolecular palladium complex G-Pd, formed via self-assembly of Pd-complex of guanidinium pillar[5]arene with Pd²⁺, was used to encapsulate doxorubicin to G-Pd@DOX. The nanoparticles exhibit responsiveness to glutathione, controlled drug release, ability to damage mitochondria, and potent anticancer activity while maintaining low toxicity towards normal cells. This work provides a good example for the application of pillararene-based palladium complexes in cancer therapy, and is significant for discovery of new medicine from supramolecular coordination complexes.
期刊介绍:
ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.