Molecular endoperoxides for optical imaging and photodynamic therapy

IF 20.3 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews Pub Date : 2024-10-04 DOI:10.1016/j.ccr.2024.216258

Dapeng Chen , Tian Zhang , Aihong Jiao , Xiaozhou Mou , Xiaochen Dong , Yu Cai

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引用次数: 0

Abstract

Molecular endoperoxide (MEPO) structuring with heterocycle peroxide (-O-O-) has shown tremendous promise for diseases diagnosis and treatment. Upon excitation by visible light, X-ray, or ultrasound, the afterglow or chemiluminescence emitted by MEPOs contribute to the development of autofluorescence-free optical imaging modes with ultrahigh signal-to-background ratio. Meanwhile, the reversible process of trapping and releasing of singlet oxygen from heterocycle substrates enables MEPOs to accomplish unconventional photodynamic effect featuring with dark and hypoxia tolerance. This review highlights the recent trends in the development of MEPOs as a powerful tool for optical imaging and photodynamic therapy (PDT). A summary was delivered to clarify the formation, decomposition, classification, and working mechanisms of MEPOs. Design strategies were also introduced with MEPOs towards a broad range of biomedical applications in optical imaging and PDT of different diseases. Lastly, perspectives and challenges for clinical translations were discussed for the direction of next-generation MEPOs.

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用于光学成像和光动力疗法的分子内过氧化物

以杂环过氧化物（-O-O-）为结构的分子过氧化物（MEPO）在疾病诊断和治疗方面显示出巨大的前景。在可见光、X 射线或超声波的激发下，MEPO 发出的余辉或化学发光有助于开发具有超高信噪比的无自发荧光光学成像模式。同时，由于单线态氧从杂环基质中捕获和释放的过程是可逆的，因此 MEPOs 能够实现非常规的光动力效应，具有耐暗和耐缺氧的特点。本综述重点介绍了 MEPOs 作为光学成像和光动力疗法 (PDT) 的有力工具的最新发展趋势。综述阐明了 MEPOs 的形成、分解、分类和工作机制。还介绍了 MEPOs 在不同疾病的光学成像和光动力疗法中广泛生物医学应用的设计策略。最后，针对下一代 MEPOs 的发展方向，讨论了临床转化的前景和挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.