Osteoprotective effect of Achyranthes bidentata root extract on osteoporotic rats: a systematic review and meta-analysis.

IF 3.9 3区 医学 Q1 MEDICAL LABORATORY TECHNOLOGY
Pharmaceutical Biology Pub Date : 2024-12-01 Epub Date: 2024-10-03 DOI:10.1080/13880209.2024.2407531
Hao Yang, Rui Tang, Hong-Li Wu, Jia-Hao Li, Chi Zhang
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引用次数: 0

Abstract

Context: Achyranthes bidentata Blume (ABB), a plant of Amaranthaceae family, has been one of the more commonly used phytomedicine remedies for thousands of years, and recent studies have highlighted the efficacy of its extracts in the treatment of osteoporosis. Nonetheless, a thorough analysis of its benefits is currently absent.

Objective: This meta-analysis assessed the effects of ABB root extract (ABBRE) on osteoporotic rats and provides a rationale for future clinical studies.

Methods: Searches were conducted in seven different Chinese and English databases, and the search period was from their establishment to January 2024. This study was registered in PROSPERO (CRD42023418917). Selected research regarding the ABBRE treatment of osteoporotic rats, and the corresponding research has distinctly reported outcomes, and the data on the bone mineral density (BMD), bone histomorphometrics, biomechanical parameters, and bone biochemical markers of osteoporotic rats can be extracted.

Results: Through screening, 11 studies met the eligibility requirements for inclusion, in which 222 animals were studied. The treatment group with ABBRE exhibited increased bone mineral density (standardized mean difference [SMD] = 1.64, 95% CI = 0.52 to 2.77). Based on subgroup analysis, the greatest increase in bone mineral density was observed when the dose of ABBRE was ≤ 400 mg/kg/day and the duration of treatment was ≤ 12 weeks.

Conclusions: ABBRE is a phytomedicine that can effectively promote the enhancement of bone mineral density and ease osteoporosis. It can be developed into a new alternative therapy by conducting experiments and clinical studies on larger samples.

牛膝根提取物对骨质疏松大鼠的骨保护作用:系统综述和荟萃分析。
背景:千百年来,苋科植物 Achyranthes bidentata Blume(ABB)一直是较常用的植物疗法之一,最近的研究强调了其提取物在治疗骨质疏松症方面的功效。然而,目前尚未对其功效进行全面分析:本荟萃分析评估了ABB根提取物(ABBRE)对骨质疏松症大鼠的影响,并为未来的临床研究提供依据:在7个不同的中英文数据库中进行检索,检索期从数据库建立到2024年1月。本研究已在 PROSPERO(CRD42023418917)上注册。筛选有关ABBRE治疗骨质疏松大鼠的研究,相应研究有明确的结果报道,可提取骨质疏松大鼠的骨矿物质密度(BMD)、骨组织形态计量学、生物力学参数和骨生化标志物等数据:通过筛选,有 11 项研究符合纳入条件,其中有 222 只动物接受了研究。ABBRE治疗组的骨矿物质密度有所增加(标准化平均差异[SMD] = 1.64,95% CI = 0.52至2.77)。根据亚组分析,当ABBRE的剂量≤400毫克/千克/天且治疗时间≤12周时,骨矿物质密度的增加幅度最大:结论:ABBRE 是一种植物药,能有效促进骨矿物质密度的提高,缓解骨质疏松症。结论:ABBRE 是一种植物药,能有效促进骨矿物质密度的提高,缓解骨质疏松症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmaceutical Biology
Pharmaceutical Biology 医学-药学
CiteScore
6.70
自引率
2.60%
发文量
191
审稿时长
1 months
期刊介绍: Pharmaceutical Biology will publish manuscripts describing the discovery, methods for discovery, description, analysis characterization, and production/isolation (including sources and surveys) of biologically-active chemicals or other substances, drugs, pharmaceutical products, or preparations utilized in systems of traditional medicine. Topics may generally encompass any facet of natural product research related to pharmaceutical biology. Papers dealing with agents or topics related to natural product drugs are also appropriate (e.g., semi-synthetic derivatives). Manuscripts will be published as reviews, perspectives, regular research articles, and short communications. The primary criteria for acceptance and publication are scientific rigor and potential to advance the field.
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