The bidirectional interplay of obstructive sleep apnea and viral respiratory infections in children: A novel opportunity for primary prevention.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2024-10-04 DOI:10.1002/ppul.27314

Gustavo Nino, Elizabeth Chorvinsky, Surajit Bhattacharya, Maria J Gutierrez

引用次数: 0

Abstract

Obstructive sleep apnea (OSA) and viral respiratory infections are highly prevalent conditions in children and a major cause of respiratory morbidity in this age group. Severe viral respiratory infections are a known risk factor for pediatric OSA, which is primarily caused by hypertrophy of upper airway lymphoid tissues (adenoids and tonsils). This review examines recent progress in understanding early-life development of lymphoid tissues in the human upper airway, with a particular focus on how respiratory viruses may influence this process and contribute to OSA pathogenesis. It also explores the bidirectional relationship between OSA and severe viral infections, highlighting the need for ongoing monitoring and novel primary prevention strategies to address these interconnected conditions.

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儿童阻塞性睡眠呼吸暂停与病毒性呼吸道感染的双向相互作用：初级预防的新机遇。

阻塞性睡眠呼吸暂停（OSA）和病毒性呼吸道感染是儿童的高发疾病，也是该年龄段儿童呼吸道疾病发病率的主要原因。严重的病毒性呼吸道感染是小儿 OSA 的已知危险因素，而 OSA 主要是由上气道淋巴组织（腺样体和扁桃体）肥大引起的。本综述探讨了了解人类上气道淋巴组织早期发育的最新进展，尤其关注呼吸道病毒如何影响这一过程并导致 OSA 发病。它还探讨了 OSA 与严重病毒感染之间的双向关系，强调了持续监测和新型初级预防策略的必要性，以解决这些相互关联的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.