Cancer neuroscience at the brain-body interface.

IF 7.5 1区 生物学 Q1 CELL BIOLOGY
Jeremy C Borniger
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引用次数: 0

Abstract

Our approaches toward understanding cancer have evolved beyond cell-intrinsic and local microenvironmental changes within the tumor to encompass how the cancer interfaces with the entire host organism. The nervous system is uniquely situated at the interface between the brain and body, constantly receiving and sending signals back and forth to maintain homeostasis and respond to salient stimuli. It is becoming clear that various cancers disrupt this dialog between the brain and body via both neuronal and humoral routes, leading to aberrant brain activity and accelerated disease. In this outlook, I discuss this view of cancer as a homeostatic challenge, emphasize cutting-edge work, and provide outstanding questions that need to be answered to move the field forward.

脑-体界面的癌症神经科学。
我们理解癌症的方法已经超越了细胞内在和肿瘤局部微环境变化的范畴,而涵盖了癌症与整个宿主机体的相互作用。神经系统位于大脑和身体的交界处,不断来回接收和发送信号,以维持体内平衡并对明显的刺激做出反应。越来越清楚的是,各种癌症通过神经元和体液途径破坏了大脑和身体之间的这种对话,导致大脑活动失常和疾病加速。在这篇展望中,我将讨论这种将癌症视为平衡挑战的观点,强调最前沿的工作,并提出需要回答的未决问题,以推动这一领域的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Genes & development
Genes & development 生物-发育生物学
CiteScore
17.50
自引率
1.90%
发文量
71
审稿时长
3-6 weeks
期刊介绍: Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).
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