Burden of neural tube defects in India: a systematic review and meta-analysis.

IF 1.3 4区医学 Q4 CLINICAL NEUROLOGY

Child's Nervous System Pub Date : 2024-10-04 DOI:10.1007/s00381-024-06627-x

Anuvi Sinha, Ponmani P, Hirok Chakraborty, Rajan Kumar Barnwal, Ratnesh Sinha

{"title":"Burden of neural tube defects in India: a systematic review and meta-analysis.","authors":"Anuvi Sinha, Ponmani P, Hirok Chakraborty, Rajan Kumar Barnwal, Ratnesh Sinha","doi":"10.1007/s00381-024-06627-x","DOIUrl":null,"url":null,"abstract":"Background: One of the most common and serious congenital defects is neural tube defect (NTD) in India. The data about the NTDs in India is lacking. The objective of this meta-analysis is to provide an estimate of NTDs in India with regional variations.Method: This study was conducted by doing a literature search using PubMed (Medline) and Embase databases for studies published from their inception to 1 October 2023 by using relevant keywords. We have prepared our study protocol by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist, and our study is registered in PROSPERO. Pooled prevalence was calculated by using the Der Simonian-Liard method and random effect model to find out the burden of NTD in India. Additionally, subgroup and sensitivity analyses were also performed. NHLBI (National Heart, Lung, and Blood Institute) tool was used for assessing the study quality.Results: A total of 1129 articles were identified by using the predefined keywords in which 27 articles were selected which were fitting the selection criteria defined in our study. The prevalence of NTDs in our meta-analysis was found to be 9.46 per 1000 births with a 95% confidence interval of 8.01 to 10.91 per 1000 births with significant heterogeneity with I2 of 99.15%.Conclusion: Our study highlights the increasing trend of NTDs over the past decades, with significant regional variation in India. There is an urgent need for comprehensive prevention strategies such as advocacy and awareness, antenatal screening for NTDs, folic acid supplementation, and food fortification. Future research is required for identification and implementation for a target-based approach for region specific.","PeriodicalId":9970,"journal":{"name":"Child's Nervous System","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Child's Nervous System","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00381-024-06627-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: One of the most common and serious congenital defects is neural tube defect (NTD) in India. The data about the NTDs in India is lacking. The objective of this meta-analysis is to provide an estimate of NTDs in India with regional variations.

Method: This study was conducted by doing a literature search using PubMed (Medline) and Embase databases for studies published from their inception to 1 October 2023 by using relevant keywords. We have prepared our study protocol by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist, and our study is registered in PROSPERO. Pooled prevalence was calculated by using the Der Simonian-Liard method and random effect model to find out the burden of NTD in India. Additionally, subgroup and sensitivity analyses were also performed. NHLBI (National Heart, Lung, and Blood Institute) tool was used for assessing the study quality.

Results: A total of 1129 articles were identified by using the predefined keywords in which 27 articles were selected which were fitting the selection criteria defined in our study. The prevalence of NTDs in our meta-analysis was found to be 9.46 per 1000 births with a 95% confidence interval of 8.01 to 10.91 per 1000 births with significant heterogeneity with I2 of 99.15%.

Conclusion: Our study highlights the increasing trend of NTDs over the past decades, with significant regional variation in India. There is an urgent need for comprehensive prevention strategies such as advocacy and awareness, antenatal screening for NTDs, folic acid supplementation, and food fortification. Future research is required for identification and implementation for a target-based approach for region specific.

查看原文本刊更多论文

印度神经管缺陷的负担：系统回顾和荟萃分析。

背景：在印度，神经管畸形（NTD）是最常见、最严重的先天性缺陷之一。印度缺乏有关 NTD 的数据。本荟萃分析的目的是提供印度 NTDs 的估计值，以及地区差异：本研究使用 PubMed（Medline）和 Embase 数据库进行文献检索，使用相关关键词搜索从开始到 2023 年 10 月 1 日发表的研究。我们按照系统综述和元分析首选报告项目（PRISMA）清单制定了研究方案，并在 PROSPERO 上进行了注册。我们采用 Der Simonian-Liard 方法和随机效应模型计算了汇总患病率，以了解印度 NTD 的负担情况。此外，还进行了亚组和敏感性分析。NHLBI（美国国家心肺血液研究所）工具用于评估研究质量：通过使用预先定义的关键词，共识别出 1129 篇文章，其中 27 篇符合我们研究中定义的选择标准。在我们的荟萃分析中发现，每 1000 名新生儿的 NTD 患病率为 9.46 例，95% 置信区间为 8.01 至 10.91 例，异质性显著，I2 为 99.15%：我们的研究表明，过去几十年来，印度的非传染性疾病呈上升趋势，且地区差异显著。迫切需要采取全面的预防策略，如宣传和提高认识、产前筛查 NTDs、补充叶酸和食品营养强化。今后需要开展研究，以确定和实施针对特定地区的目标方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Child's Nervous System 医学-临床神经学

CiteScore

3.00

自引率

7.10%

发文量

322

审稿时长

3 months

期刊介绍： The journal has been expanded to encompass all aspects of pediatric neurosciences concerning the developmental and acquired abnormalities of the nervous system and its coverings, functional disorders, epilepsy, spasticity, basic and clinical neuro-oncology, rehabilitation and trauma. Global pediatric neurosurgery is an additional field of interest that will be considered for publication in the journal.