Synthetic nanomaterials for spleen-specific mRNA delivery

IF 12.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Biomaterials Pub Date : 2024-09-28 DOI:10.1016/j.biomaterials.2024.122859

Shihong Nie , Beiqi Yang , Ruiying Ma , Lili Zha , Yuyang Qin , Liyuan Ou , Xiaoyuan Chen , Ling Li

引用次数: 0

Abstract

In recent years, mRNA vaccine has achieved increasing interest owing to its high potency, safety, ease of production, and low-cost manufacturing. Currently approved mRNA vaccines are administered intramuscularly to transfect local antigen-presenting cells (APCs) to initiate low to moderate immune responses. Spleen, the largest secondary lymphoid organ in the body which contains a large number of APCs close to B and T lymphocytes, could be the ideal site for effective initiation of an enhanced immune response. Here, we provide an overview of the recent advances in the development of synthetic materials for spleen-specific mRNA delivery, and lipid nanoparticle-based approaches will be highlighted. We further discuss the main challenges for spleen-specific mRNA delivery to provide a reference for the development of next-generation synthetic nanomaterials with optimal properties.

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用于脾脏特异性 mRNA 递送的合成纳米材料。

近年来，mRNA 疫苗因其效力高、安全性好、易于生产和制造成本低而受到越来越多的关注。目前获批的 mRNA 疫苗通过肌肉注射转染局部抗原递呈细胞 (APC)，以启动中低度免疫反应。脾脏是人体内最大的次级淋巴器官，含有大量接近 B 淋巴细胞和 T 淋巴细胞的 APCs，可能是有效启动增强免疫反应的理想部位。在此，我们将概述最近在开发用于脾脏特异性 mRNA 递送的合成材料方面取得的进展，并重点介绍基于脂质纳米粒子的方法。我们将进一步讨论脾脏特异性 mRNA 递送所面临的主要挑战，为开发具有最佳性能的下一代合成纳米材料提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomaterials 工程技术-材料科学：生物材料

CiteScore

26.00

自引率

2.90%

发文量

565

审稿时长

46 days

期刊介绍： Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.