PRC2-RNA interactions: Viewpoint from Tom Cech, Chen Davidovich, and Richard Jenner

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-10-03 DOI:10.1016/j.molcel.2024.09.010

Thomas R. Cech, Chen Davidovich, Richard G. Jenner

引用次数: 0

Abstract

Diverse biochemical, structural, and in vivo data support models for the regulation of polycomb repressive complex 2 (PRC2) activity by RNAs, which may contribute to the maintenance of epigenetic states. Here, we summarize this research and also suggest why it can be difficult to capture biologically relevant PRC2-RNA interactions in living cells.

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PRC2-RNA 相互作用：Tom Cech、Chen Davidovich 和 Richard Jenner 的观点

多种生化、结构和体内数据支持 RNA 调节多聚核抑制复合体 2（PRC2）活性的模型，这可能有助于表观遗传状态的维持。在此，我们对这些研究进行了总结，并提出了为什么在活细胞中难以捕捉到与生物学相关的 PRC2-RNA 相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.