50 years in the making: acp3U, an amino-acid-containing nucleoside, links N-glycans and RNA in glycoRNA

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-10-03 DOI:10.1016/j.molcel.2024.09.014

Kfir B. Steinbuch, Yitzhak Tor

引用次数: 0

Abstract

In a recent publication in Cell, Xie et al.¹ report a sensitive and scalable method for the detection and characterization of native glycoRNAs and identify acp³U, an abundant modified nucleoside discovered 50 years ago in tRNA^Phe, as one of the primary attachment sites for N-glycans.

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50 年历程：含氨基酸的核苷 acp3U 在糖核糖核酸中将 N-糖和核糖核酸连接起来

在最近发表于《细胞》（Cell）的一篇文章中，Xie 等人1 报道了一种灵敏且可扩展的方法，用于检测和表征原生的糖核糖核酸，并将 50 年前在 tRNAPhe 中发现的一种丰富的修饰核苷--acp3U 确定为 N-糖的主要附着位点之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.