The challenges of investigating RNA function

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-10-03 DOI:10.1016/j.molcel.2024.08.019

Li Yang, Igor Ulitsky, Wendy V. Gilbert, Chengqi Yi, Jernej Ule, Maïwen Caudron-Herger

引用次数: 0

Abstract

High-throughput sequencing methods have led to the discovery of many non-coding RNAs, RNA modifications, and protein-RNA interactions. While the list keeps growing, the challenge of determining their functions remains. For our focus issue on RNA biology, we spoke with several researchers about their perspective on investigating the functions of RNA.

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研究 RNA 功能面临的挑战

高通量测序方法发现了许多非编码 RNA、RNA 修饰以及蛋白质与 RNA 之间的相互作用。虽然发现的数量在不断增加，但确定其功能的挑战依然存在。针对我们的 RNA 生物学焦点问题，我们采访了几位研究人员，了解他们对研究 RNA 功能的看法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.