Theta phase precession supports memory formation and retrieval of naturalistic experience in humans

IF 21.4 1区 心理学 Q1 MULTIDISCIPLINARY SCIENCES
Jie Zheng, Mar Yebra, Andrea G. P. Schjetnan, Kramay Patel, Chaim N. Katz, Michael Kyzar, Clayton P. Mosher, Suneil K. Kalia, Jeffrey M. Chung, Chrystal M. Reed, Taufik A. Valiante, Adam N. Mamelak, Gabriel Kreiman, Ueli Rutishauser
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Abstract

Associating different aspects of experience with discrete events is critical for human memory. A potential mechanism for linking memory components is phase precession, during which neurons fire progressively earlier in time relative to theta oscillations. However, no direct link between phase precession and memory has been established. Here we recorded single-neuron activity and local field potentials in the human medial temporal lobe while participants (n = 22) encoded and retrieved memories of movie clips. Bouts of theta and phase precession occurred following cognitive boundaries during movie watching and following stimulus onsets during memory retrieval. Phase precession was dynamic, with different neurons exhibiting precession in different task periods. Phase precession strength provided information about memory encoding and retrieval success that was complementary with firing rates. These data provide direct neural evidence for a functional role of phase precession in human episodic memory. Zheng et al. show neural evidence for a functional role of phase precession in human episodic memory.

Abstract Image

Abstract Image

Theta 相序支持人类自然体验记忆的形成和检索
将不同方面的经验与离散事件联系起来对人类记忆至关重要。相位前冲是将记忆成分联系起来的一种潜在机制,在相位前冲期间,神经元相对于θ振荡在时间上逐渐提前发射。然而,相位前冲与记忆之间的直接联系尚未建立。在这里,我们记录了人类内侧颞叶的单神经元活动和局部场电位,当时参与者(22 人)正在编码和检索电影片段的记忆。在观看电影和检索记忆时,θ 和相位前移分别出现在认知边界和刺激开始之后。相位前冲是动态的,不同的神经元在不同的任务期间表现出不同的前冲。相位前冲强度提供了有关记忆编码和检索成功的信息,与发射率相辅相成。这些数据为相位前冲在人类外显记忆中的功能作用提供了直接的神经证据。
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来源期刊
Nature Human Behaviour
Nature Human Behaviour Psychology-Social Psychology
CiteScore
36.80
自引率
1.00%
发文量
227
期刊介绍: Nature Human Behaviour is a journal that focuses on publishing research of outstanding significance into any aspect of human behavior.The research can cover various areas such as psychological, biological, and social bases of human behavior.It also includes the study of origins, development, and disorders related to human behavior.The primary aim of the journal is to increase the visibility of research in the field and enhance its societal reach and impact.
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