Changes in the Liver Function and Hematological Parameters in Dengue Patients at a Tertiary Care Center: A Descriptive Cross-sectional Study.

IF 0.5 4区医学 Q3 Medicine

Journal of Nepal Medical Association Pub Date : 2024-05-31 DOI:10.31729/jnma.8616

Asmita Pokharel, Buddhi Pokhrel, Richa Bhattarai, Madhav Khanal

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引用次数: 0

Abstract

Introduction: Liver is most commonly affected in dengue often resulting in changes in the liver function test parameters. Alterations in hematological parameters are also reported which could serve as early prognostic markers especially in resource limited settings where serological tests for the diagnosis of dengue is not available. This study aims to analyze liver function test and hematological parameter changes in dengue infected patients.

Methods: A descriptive cross-sectional study was conducted from December 2022 to October 2023 in serologically dengue positive patients. Liver function parameters and blood parameters were analyzed from 220 patients. The purposive sampling technique was employed during the selection of participants.

Results: Out of 220 study participants, 113 (51.36%) were males and 107 (49.64%) were females. The median age of the participants was 35 years (IQR: 26 - 48 years). Elevated serum AST and ALT levels were present in 121 (55%) and 80 (36.36%) of the participants respectively. Thrombocytopenia and leukopenia were observed in 92 (41.82%) and 88 (40%) of the study participants respectively. The median hemoglobin level was 14.4 (IQR: 13-15.47) g/dl. Low hemoglobin level was found in 31 (14.09%) participants. The median red blood cell count was 4.91 (IQR: 4.49 - 5.28) millions/mm3 with decreased red blood cell count noted in 27 (12.27%) participants.

Conclusions: Increased serum transaminases levels, thrombocytopenia and leukopenia are common laboratory findings in dengue patients.

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一家三级医疗中心登革热患者肝功能和血液学参数的变化：描述性横断面研究。

导言：登革热最常影响肝脏，导致肝功能检测指标发生变化。血液学参数的变化也有报道，这可作为早期预后的标志物，尤其是在资源有限、无法进行登革热血清学检测的情况下。本研究旨在分析登革热感染者的肝功能检测和血液学参数变化：方法：2022 年 12 月至 2023 年 10 月对血清学登革热阳性患者进行了描述性横断面研究。对 220 名患者的肝功能参数和血液参数进行了分析。在选择参与者时采用了目的性抽样技术：在 220 名研究参与者中，男性 113 人（51.36%），女性 107 人（49.64%）。参与者的年龄中位数为 35 岁（IQR：26 - 48 岁）。121人（55%）和 80人（36.36%）的血清谷草转氨酶和谷丙转氨酶水平升高。分别有 92 人（41.82%）和 88 人（40%）出现血小板减少和白细胞减少。血红蛋白水平中位数为 14.4（IQR：13-15.47）克/分升。31人（14.09%）的血红蛋白水平偏低。红细胞计数中位数为 4.91（IQR：4.49 - 5.28）百万/立方毫米，其中 27 人（12.27%）的红细胞计数减少：结论：血清转氨酶水平升高、血小板减少和白细胞减少是登革热患者常见的实验室检查结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nepal Medical Association PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-MEDICINE, GENERAL & INTERNAL

CiteScore

1.00

自引率

0.00%

发文量

233

审稿时长

>12 weeks

期刊介绍： Journal of Nepal Medical Association is an internationally peer-reviewed, MedLine/PubMed indexed, a monthly general medical journal published by Nepal Medical Association. JNMA is the first and oldest medical journal from Nepal since 1963 AD.