Splenic nociceptive neural connection promotes humoral immunity.

IF 14.6 1区医学 Q1 NEUROSCIENCES

Trends in Neurosciences Pub Date : 2024-10-01 DOI:10.1016/j.tins.2024.09.008

Cheng Qian, Jiaming Wang, Xuetao Cao

引用次数: 0

Abstract

Recent work by Wu and colleagues unveiled a previously enigmatic population of spleen-innervating nociceptors from left T8-T13 dorsal root ganglia (DRGs) in mice. They found a specific DRG-spleen sensorineural connection that promotes humoral immunity via a CGRP-CALCRL/RAMP1 axis, providing a valuable target for immune regulation in local microenvironments.

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脾脏痛觉神经连接可促进体液免疫。

Wu及其同事最近的研究揭示了小鼠左侧T8-T13背根神经节（DRGs）的脾脏神经感受器群，这在以前是一个谜。他们发现了一种特定的 DRG-脾脏感觉神经连接，这种连接通过 CGRP-CALCRL/RAMP1 轴促进体液免疫，为局部微环境中的免疫调节提供了一个有价值的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Neurosciences 医学-神经科学

CiteScore

26.50

自引率

1.30%

发文量

123

审稿时长

6-12 weeks

期刊介绍： For over four decades, Trends in Neurosciences (TINS) has been a prominent source of inspiring reviews and commentaries across all disciplines of neuroscience. TINS is a monthly, peer-reviewed journal, and its articles are curated by the Editor and authored by leading researchers in their respective fields. The journal communicates exciting advances in brain research, serves as a voice for the global neuroscience community, and highlights the contribution of neuroscientific research to medicine and society.