Heteroresistance: a hidden cause behind antifungal prophylaxis failure.

IF 14 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Microbiology Pub Date : 2024-11-01 Epub Date: 2024-10-01 DOI:10.1016/j.tim.2024.09.008

Anaïs Hérivaux, Nicolas Papon, Florent Morio

引用次数: 0

Abstract

Invasive fungal infections in allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients on antimicrobial prophylaxis is a major cause of infectious mortality, although its underlying pathophysiological mechanisms remain unclear. In a new report, Zhai and colleagues provide evidence that heteroresistance drives breakthrough Candida parapsilosis bloodstream infections in allo-HSCT recipients receiving micafungin prophylaxis.

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异抗性：抗真菌预防失败背后的隐患。

异基因造血干细胞移植（allo-HSCT）受者在接受抗菌素预防治疗时发生的侵袭性真菌感染是感染性死亡的主要原因，但其潜在的病理生理机制仍不清楚。在一份新的报告中，Zhai及其同事提供了证据，证明异种抗药性是接受米卡芬净预防治疗的异体造血干细胞移植受者发生突破性副丝状念珠菌血流感染的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Microbiology 生物-生化与分子生物学

CiteScore

25.30

自引率

0.60%

发文量

193

审稿时长

6-12 weeks

期刊介绍： Trends in Microbiology serves as a comprehensive, multidisciplinary forum for discussing various aspects of microbiology, spanning cell biology, immunology, genetics, evolution, virology, bacteriology, protozoology, and mycology. In the rapidly evolving field of microbiology, technological advancements, especially in genome sequencing, impact prokaryote biology from pathogens to extremophiles, influencing developments in drugs, vaccines, and industrial enzyme research.