Challenges in the care of cystic fibrosis in low-to-middle income countries.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2024-10-03 DOI:10.1002/ppul.27294

Sushil Kr Kabra

引用次数: 0

Abstract

Till few years ago cystic fibrosis (CF) was considered to be exclusively disease affecting Caucasian population. More recently CF has been reported from all over the world from different ethnic background. CF is an emerging illness in other parts of world (India with 1:2200 to 1:40,000 live birth). In low- and middle-income countries (LMICs) diagnosis of CF is missed due to ignorance and nonavailability of diagnostic tests. Diagnosis can be made using clinical features and basic lab tests. As of now there is no cure, but supportive care improved survival. However, medicines used in higher income countries are very expensive and not accessible to children with CF in LMICs. Cystic fibrosis transmembrane regulators modulators have emerged as significant advances in management. These are very expensive and beyond the reach of patients in LMICs. CF Fraternity in developed countries should work towards training of personnel and possibly making medications available in LMICs.

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中低收入国家在治疗囊性纤维化方面面临的挑战。

几年前，囊性纤维化（CF）还被认为是只影响白种人的疾病。最近，世界各地不同种族背景的人都有患囊性纤维化的报道。在世界其他地区，CF 是一种新出现的疾病（在印度，1:2200 到 1:40000 的活产婴儿中就有 CF 患者）。在低收入和中等收入国家（LMICs），由于对 CF 的不了解和无法获得诊断测试，CF 的诊断被遗漏。可通过临床特征和基本实验室检查进行诊断。目前尚无治愈方法，但支持性护理可提高存活率。然而，高收入国家使用的药物非常昂贵，低收入和中等收入国家的 CF 儿童无法获得。囊性纤维化跨膜调节剂调节剂的出现是治疗方面的重大进展。这些药物非常昂贵，低收入国家的患者无法负担。发达国家的CF兄弟会应努力培训人员，并在可能的情况下在低收入和中等收入国家提供药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.