Short-Term Trigeminal Ganglion Stimulation in Patients with Multi-Branch Trigeminal Herpetic Neuralgia: A Pilot Study.

IF 2.6 2区医学 Q2 ANESTHESIOLOGY

Pain physician Pub Date : 2024-09-01

Yong Zhang, Yanqing Wu, Cuihua Jiang, Ziwei Yang, Xuexue Zhang, Daying Zhang, Fan Yang, Yi Yan

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引用次数: 0

Abstract

Background: Trigeminal herpetic neuralgia (THN) presents with severe pain hyperalgesia and is a high-risk factor for postherpetic neuralgia (PHN). The current clinical treatments for THN are unsatisfactory, and new treatments are desperately required.

Objectives: This pilot study aimed to evaluate the efficacy of short-term trigeminal ganglion stimulation in treating patients with multi-branch THN.

Study design: A prospective pilot study.

Setting: Multi-center study in 3 academic hospitals.

Methods: From July 2021 to October 2022, we enrolled 20 patients with multi-branch THN who received short-term trigeminal ganglion stimulation under general anesthesia from 3 hospitals. All patients completed a 12-month follow-up. The visual analog scale (VAS) and Pittsburgh Sleep Quality Index (PSQI) were used to assess patients' pain and quality of sleep. The Barrow Neurological Institute (BNI) score was used to determine the global outcome of pain relief, and complications were recorded.

Results: Significant and sustained pain relief and sleep improvement were achieved by all the patients who underwent trigeminal ganglion electrode stimulation in the present study. Respective BNI scores of 80% and 85% at 3 and 12 months after surgery were considered good. There were no other serious complications except for 2 patients' experiences of transient trigeminal cardiac reflex during the surgery and transient numbness deterioration in one patient's V3 sensory area.

Limitations: The present study is a pilot study. We expect prospective multi-center, large-sample studies in the future.

Conclusion: Short-term trigeminal ganglion stimulation can be used safely and effectively to treat patients with multi-branch THN and significantly reduce the occurrence of PHN.

本刊更多论文

多支三叉神经疱疹性神经痛患者的三叉神经节短期刺激：试点研究。

背景：三叉神经疱疹性神经痛（THN）表现为严重的痛觉减退，是带状疱疹后遗神经痛（PHN）的高危因素。目前治疗疱疹性神经痛的临床方法并不令人满意，迫切需要新的治疗方法：本试验性研究旨在评估短期三叉神经节刺激治疗多分支 THN 患者的疗效：研究设计：前瞻性试验研究：在3家学术医院开展多中心研究：从 2021 年 7 月到 2022 年 10 月，我们从 3 家医院招募了 20 名多支 THN 患者，他们在全身麻醉下接受了短期三叉神经节刺激治疗。所有患者均完成了为期 12 个月的随访。采用视觉模拟量表（VAS）和匹兹堡睡眠质量指数（PSQI）评估患者的疼痛和睡眠质量。巴罗神经研究所（Barrow Neurological Institute，BNI）评分用于确定疼痛缓解的总体结果，并记录并发症：结果：在本研究中，所有接受三叉神经节电极刺激的患者都获得了明显、持续的疼痛缓解和睡眠改善。术后 3 个月和 12 个月的 BNI 评分分别达到 80% 和 85% 即为良好。除了两名患者在手术过程中出现一过性三叉神经心脏反射和一名患者的V3感觉区出现一过性麻木恶化外，没有其他严重并发症：本研究只是一项试点研究。局限性：本研究只是一项试验性研究，我们希望将来能开展多中心、大样本的前瞻性研究：短期三叉神经节刺激可安全有效地治疗多支 THN 患者，并显著减少 PHN 的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pain physician CLINICAL NEUROLOGY-CLINICAL NEUROLOGY

CiteScore

6.00

自引率

21.60%

发文量

234

期刊介绍： Pain Physician Journal is the official publication of the American Society of Interventional Pain Physicians (ASIPP). The open access journal is published 6 times a year. Pain Physician Journal is a peer-reviewed, multi-disciplinary, open access journal written by and directed to an audience of interventional pain physicians, clinicians and basic scientists with an interest in interventional pain management and pain medicine. Pain Physician Journal presents the latest studies, research, and information vital to those in the emerging specialty of interventional pain management – and critical to the people they serve.