Astrocyte-neuron crosstalk in neurodevelopmental disorders

IF 4.8 2区医学 Q1 NEUROSCIENCES

Current Opinion in Neurobiology Pub Date : 2024-10-01 DOI:10.1016/j.conb.2024.102925

Gabrielle Séjourné , Cagla Eroglu

引用次数: 0

Abstract

A fundamental feature shared across neurodevelopmental disorders (NDDs) is the disruption of synaptic circuit formation and homeostasis. During early life, non-neuronal cells called astrocytes tightly regulate the establishment of circuits by controlling formation, remodeling, stabilization, and maturation of synapses. Concurrently, astrocytes mature to meet the evolving needs of the developing brain. Bidirectional astrocyte-neuron communication synchronizes astrocyte maturation with synapse development. An emerging body of evidence supports the hypothesis that in NDDs, deficits in astrocyte-neuron communication underlie errors in synaptic circuit development. Here we will review and discuss these findings, with the aim of inspiring future research and guiding translational studies.

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神经发育障碍中的星形胶质细胞-神经元串扰

神经发育障碍（NDDs）的一个共同基本特征是突触回路的形成和平衡受到破坏。在生命早期，被称为星形胶质细胞的非神经元细胞通过控制突触的形成、重塑、稳定和成熟，密切调节回路的建立。与此同时，星形胶质细胞也在不断成熟，以满足大脑发育过程中不断变化的需求。星形胶质细胞与神经元之间的双向交流使星形胶质细胞的成熟与突触的发育同步进行。越来越多的证据支持这样一种假设，即在 NDD 中，星形胶质细胞与神经元交流的缺陷是突触回路发育错误的根源。在此，我们将回顾并讨论这些发现，旨在启发未来的研究并指导转化研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Neurobiology 医学-神经科学

CiteScore

11.10

自引率

1.80%

发文量

130

审稿时长

4-8 weeks

期刊介绍： Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience