Genetic and non-genetic HLA disruption is widespread in lung and breast tumors

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-10-02 DOI:10.1038/s41588-024-01886-5

引用次数: 0

Abstract

Immune recognition of cancers can be inhibited if the molecules that present cancer cell-specific antigens are disrupted. We have developed a tool that can detect four different types of disruption. Overall, we find that both genetic and non-genetic disruption of these molecules is common in lung and breast tumors.

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遗传性和非遗传性 HLA 干扰广泛存在于肺癌和乳腺癌中

如果呈现癌细胞特异性抗原的分子受到破坏，癌症的免疫识别就会受到抑制。我们开发了一种工具，可以检测四种不同类型的破坏。总体而言，我们发现这些分子的基因和非基因干扰在肺癌和乳腺癌中都很常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution