Methods for Establishing a Rat Model of Rheumatic Heart Disease.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-24 eCollection Date: 2024-09-01 DOI:10.31083/j.rcm2509346

Shenglin Xian, Zhiyu Zeng

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Abstract

Rheumatic heart disease (RHD) is responsible for nearly 250,000 deaths annually and poses a significant health threat in developing areas. The unclear pathogenesis of RHD makes the development of cost-effective treatments challenging, particularly as current surgical options are expensive and technologically demanding, exacerbating the economic and quality-of-life burdens for patients. Given the risks associated with direct human experimentation due to the uncertain pathogenesis, using a rat model infected with Group A Streptococcus (GAS) has become a crucial experimental strategy for RHD research. The development of an RHD rat model, refined over 23 years, now stands as a pivotal approach in studies aiming to understand the disease's pathogenesis. This review summarizes the evolution, characteristics, advantages, and limitations of the RHD rat model, offering insights into potential areas for improvement. It aims to provide researchers with a comprehensive understanding of the model, supporting the advancement of research methodologies and the discovery of innovative treatments for RHD.

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建立风湿性心脏病大鼠模型的方法

风湿性心脏病（RHD）每年造成近 25 万人死亡，对发展中地区的健康构成严重威胁。风湿性心脏病的发病机理尚不明确，因此开发具有成本效益的治疗方法具有挑战性，特别是目前的手术方案费用昂贵且技术要求高，加重了患者的经济负担和生活质量。由于发病机制不确定，直接进行人体实验存在风险，因此使用感染 A 组链球菌（GAS）的大鼠模型已成为 RHD 研究的重要实验策略。RHD大鼠模型的开发经过23年的改进，现已成为了解该疾病发病机制研究的关键方法。本综述总结了 RHD 大鼠模型的演变、特点、优势和局限性，并对潜在的改进领域提出了见解。其目的是让研究人员对该模型有一个全面的了解，支持研究方法的进步和发现治疗 RHD 的创新疗法。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.