{"title":"Diagnostic issues in neuroendocrine neoplasms of the lung.","authors":"Atsuko Kasajima, Günter Klöppel","doi":"10.1007/s00292-024-01360-3","DOIUrl":null,"url":null,"abstract":"<p><p>Bronchopulmonary neuroendocrine neoplasms (BP-NENs) account for approximately 30% of all NENs. Although BP-NENs and NENs of the gastroenteropancreatic organs (GEP-NENs) share morphological and molecular features, they differ in terms of their terminology and classification. Bronchopulmonary neuroendocrine tumors (BP-NETs) have classically been termed as carcinoid and grouped into typical (TC) and atypical carcinoid (AC) based on the presence or absence of necrosis and mitotic count. In the most recent World Health Organization (WHO) classification for NENs of endocrine organs (WHO 2022), BP-NETs-NET G1 and G2-are introduced as synonyms of TC and AC, respectively. However, the Ki-67 index, which defines the grade of NETs in digestive organs, is only discussed in the descriptive text and not included into the criteria for classification of BP-NENs. In addition, well-differentiated NENs with high mitotic counts which correspond to NET G3 in the GEP organ system are not defined. This review discusses the role of Ki-67 for a proper classification of BP-NETs/carcinoids.</p>","PeriodicalId":74402,"journal":{"name":"Pathologie (Heidelberg, Germany)","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pathologie (Heidelberg, Germany)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00292-024-01360-3","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Bronchopulmonary neuroendocrine neoplasms (BP-NENs) account for approximately 30% of all NENs. Although BP-NENs and NENs of the gastroenteropancreatic organs (GEP-NENs) share morphological and molecular features, they differ in terms of their terminology and classification. Bronchopulmonary neuroendocrine tumors (BP-NETs) have classically been termed as carcinoid and grouped into typical (TC) and atypical carcinoid (AC) based on the presence or absence of necrosis and mitotic count. In the most recent World Health Organization (WHO) classification for NENs of endocrine organs (WHO 2022), BP-NETs-NET G1 and G2-are introduced as synonyms of TC and AC, respectively. However, the Ki-67 index, which defines the grade of NETs in digestive organs, is only discussed in the descriptive text and not included into the criteria for classification of BP-NENs. In addition, well-differentiated NENs with high mitotic counts which correspond to NET G3 in the GEP organ system are not defined. This review discusses the role of Ki-67 for a proper classification of BP-NETs/carcinoids.
支气管肺神经内分泌肿瘤（BP-NENs）约占所有 NENs 的 30%。尽管支气管肺内分泌瘤和胃肠胰器官内分泌瘤（GEP-NENs）具有相同的形态学和分子特征，但它们在术语和分类方面却有所不同。支气管肺神经内分泌肿瘤（BP-NETs）通常被称为类癌，并根据有无坏死和有丝分裂计数分为典型类癌（TC）和非典型类癌（AC）。在世界卫生组织（WHO）最新的内分泌器官类癌分类（WHO 2022）中，BP-NET-NET G1 和 G2-被分别作为 TC 和 AC 的同义词。然而，定义消化器官NET分级的Ki-67指数仅在描述性文字中讨论，并未纳入BP-NET的分类标准。此外，与 GEP 器官系统中 NET G3 相对应的有丝分裂计数高的分化良好的 NEN 也未被定义。本综述讨论了Ki-67对BP-NET/类癌正确分类的作用。
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