Long-Term Prognostic Significance of Three-Dimensional Speckle-Tracking Echocardiography-Derived Left Ventricular Twist in Healthy Adults-Results from the MAGYAR-Healthy Study.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2024-09-10 eCollection Date: 2024-09-01 DOI:10.31083/j.rcm2509324
Attila Nemes, Árpád Kormányos, Dorottya Lilla Olajos, Alexandru Achim, Zoltán Ruzsa, Nóra Ambrus, Csaba Lengyel
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引用次数: 0

Abstract

Background: The left ventricular (LV) rotational mechanics are of particular importance in the function of the LV. The rotational movement is the consequence of the arrangement of the subepicardial and subendocardial muscle fibers. These muscle fibers are perpendicular to each other, their contraction creates a characteristic motion. The aim of the present study was to examine the prognostic impact of LV twist assessed by three-dimensional speckle-tracking echocardiography (3D-STE) in healthy circumstances.

Methods: 302 healthy adults participated in the study, 181 subjects were excluded due to certain reasons (LV could not be analysed during 3D-STE, subjects were unidentifiable, or lost to follow-up). 121 subjects were involved in the final analysis (mean age of 33.1 ± 12.3 years, 75 males), who were willing to be examined on a voluntary basis.

Results: During a mean follow-up of 7.93 ± 4.21 years, 11 healthy adults suffered a cardiovascular event including 2 cardiac deaths. Using receiver operating characteristic analysis, LV twist ≥14.65 degrees as assessed by 3D-STE proved to be significantly predictive regarding the cardiovascular event-free survival (area under the curve 0.70, specificity 70%, sensitivity 65%, p = 0.028). Subjects with LV twist ≥14.65 degrees had higher basal and apical rotations and a significantly higher ratio of these individuals developed cardiovascular events compared to cases with LV twist <14.65 degrees. Subjects with cardiovascular events had lower LV global longitudinal strain, higher basal LV rotation and twist and the ratio of subjects with LV twist ≥14.65 degrees was elevated as compared to cases without events.

Conclusions: 3D-STE-derived LV twist independently predicts future cardiovascular events in healthy adults.

三维斑点追踪超声心动图得出的健康成年人左心室扭转的长期预后意义--MAGYAR-Healthy 研究的结果。
背景:左心室旋转力学对左心室的功能尤为重要。旋转运动是心外膜下和心内膜下肌纤维排列的结果。这些肌纤维相互垂直,它们的收缩产生了特有的运动。本研究的目的是通过三维斑点追踪超声心动图(3D-STE)评估健康人左心室扭转对预后的影响。方法:302 名健康成年人参与研究,181 名受试者因某些原因被排除在外(3D-STE 无法分析左心室、受试者身份无法确认或失去随访)。121名受试者(平均年龄为33.1±12.3岁,75名男性)自愿接受了最终分析:结果:在平均 7.93 ± 4.21 年的随访期间,11 名健康成年人发生了心血管事件,其中 2 人死于心脏病。通过接收器操作特征分析,3D-STE 评估的左心室扭转度≥14.65 度被证明可显著预测无心血管事件生存率(曲线下面积 0.70,特异性 70%,敏感性 65%,P = 0.028)。左心室扭转≥14.65度的受试者基底和心尖旋转更高,与左心室扭转的病例相比,这些人发生心血管事件的比例明显更高:3D-STE 导出的左心室扭转可独立预测健康成年人未来的心血管事件。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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