Correlation between triglyceride-glucose index and diabetic kidney disease risk in adults with type 1 diabetes mellitus.

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2024-10-01 DOI:10.1186/s13098-024-01468-9

Mengyun Lei, Ping Ling, Yongwen Zhou, Jing Lv, Ying Ni, Hongrong Deng, Chaofan Wang, Daizhi Yang, Xubin Yang, Wen Xu, Jinhua Yan

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Abstract

Background: The triglyceride-glucose (TyG) index is identified as an alternative indicator of insulin resistance (IR) and is associated with macro- and micro-vascular diseases among patients with type 2 diabetes mellitus. The relationship between the TyG index and IR and its impact on diabetic kidney disease (DKD) remains unclear among adults with type 1 diabetes mellitus(T1DM).

Methods: This study comprised a cross-sectional analysis using data from the Guangdong T1DM Translational Medicine Study (GTT) and a longitudinal analysis using data from the type 1 diabetes (T1D) Exchange registry study. Correlation analysis was used to investigate the association between the TyG index and IR. Logistic regression and Cox proportional hazards regression were performed to explore the impact of the TyG index on DKD risk.

Results: The GTT Study included 836 adults (216 with DKD and 620 without DKD). A significant correlation existed between the TyG index and the estimated glucose disposal rate (r=-0.64, p < 0.01). The TyG index was a risk factor for DKD after confounder adjustment (OR = 1.34, 95% CI:1.03-1.74). The T1D Exchange registry study included 8,771 adults (2,050 with DKD and 6,721 without DKD). After adjusting confounding factors, the TyG index was identified as an independent risk factor for DKD at enrollment, with the highest risk of DKD incidence observed in the highest TyG tertile group (OR = 1.92, 95%CI:1.67-2.20). During a median follow-up of 44.58(21.84, 67.09) months, the risk of developing DKD was increased by 32% at every 1 SD increase of the TyG index over time among participants without DKD at enrollment.

Conclusions: The TyG index could be used to assess IR and was identified as an independent risk factor of DKD among adults with T1DM.

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1 型糖尿病成人患者甘油三酯-葡萄糖指数与糖尿病肾病风险之间的相关性。

背景：甘油三酯-葡萄糖（TyG）指数被认为是胰岛素抵抗（IR）的替代指标，与2型糖尿病患者的大血管和微血管疾病有关。在1型糖尿病（T1DM）成人患者中，TyG指数与IR之间的关系及其对糖尿病肾病（DKD）的影响仍不清楚：本研究包括利用广东T1DM转化医学研究（GTT）数据进行的横断面分析和利用1型糖尿病（T1D）交流登记研究数据进行的纵向分析。相关分析用于研究TyG指数与IR之间的关系。为探讨TyG指数对DKD风险的影响，进行了逻辑回归和Cox比例危险度回归：GTT研究纳入了836名成年人（216名DKD患者和620名非DKD患者）。TyG指数与估计的葡萄糖处置率之间存在明显的相关性（r=-0.64，p 结论：TyG指数可用于预测DKD风险：TyG指数可用于评估IR，并被确定为T1DM成人中DKD的独立风险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.