Adiposity throughout Adulthood and Risk of Young Onset Breast Cancer Tumor Subtypes in the Young Women's Health History Study.

IF 3.7 3区医学 Q2 ONCOLOGY

Cancer Epidemiology Biomarkers & Prevention Pub Date : 2024-10-02 DOI:10.1158/1055-9965.EPI-24-1067

Lydia Marcus Post, Dorothy R Pathak, Ann S Hamilton, Kelly A Hirko, Richard T Houang, Emily H Guseman, Dan Sanfelippo, Nicole Bohme Carnegie, L Karl Olson, Hallgeir Rui, Ann G Schwartz, Ellen M Velie

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引用次数: 0

Abstract

Background: The role of adult adiposity in young-onset breast cancer (YOBC) subtype risk is not well understood.

Methods: In this population-based case(n=1812)-control(n=1381) study of invasive YOBC (aged <50 years), cases were identified from the Los Angeles County and Metropolitan Detroit SEER registries, 2010-2015. Area-based, frequency-matched controls were sampled from the 2010 Census. General adiposity (body mass index (BMI)) and central adiposity (waist circumference (WC), waist-to-height ratio (WHtR)) across adulthood and covariates were collected from in-person interviews and measurements. Odds ratios (ORs) and 95% confidence intervals (CIs) for adiposity and YOBC tumor subtypes (i.e., luminal A, luminal B, HER2+, triple negative (TN)) were calculated, overall and by parity, using multivariable weighted logistic regression.

Results: Obese young adult BMI was inversely associated with luminal A YOBC (OR=0.35, 95% CI 0.16-0.79); other subtype associations were non-significant. Similarly, adult overweight and obese BMIs were inversely associated with luminal A (respectively OR=0.66, 95% CI 0.48-0.91 and OR=0.59, 95% CI 0.46-0.87), but not other subtypes. Conversely, larger WC was associated with higher odds of luminal B and TN YOBC (respectively OR=1.48, 95% CI 1.01-2.15 and OR=2.48, 95% CI 1.52-3.88), but not other subtypes (with similar results for WHtR); highest odds were among parous women.

Conclusions: Findings show greater general adult adiposity is associated with reduced odds of luminal A YOBC, while greater central adiposity is associated with increased odds of luminal B and TN YOBC, particularly among parous women.

Impact: Additional studies of central adiposity and YOBC subtype risk, especially incorporating pregnancy history, are warranted.

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年轻女性健康史研究》中成年后的肥胖与年轻乳腺癌肿瘤亚型的风险。

背景：成人脂肪在年轻乳腺癌（YOBC）亚型风险中的作用尚不清楚：成人脂肪在年轻乳腺癌（YOBC）亚型风险中的作用尚不十分清楚：在这项以人群为基础的病例（1812 例）-对照（1381 例）研究中，研究对象为浸润性 YOBC（年龄：20 岁结果：肥胖的年轻成人 BMI 与管腔 A 型 YOBC 成反比：肥胖的年轻成人体重指数与管腔A型YOBC成反比（OR=0.35，95% CI 0.16-0.79）；其他亚型的相关性不显著。同样，成人超重和肥胖的体重指数与管腔 A 成反比（分别为 OR=0.66，95% CI 0.48-0.91 和 OR=0.59，95% CI 0.46-0.87），但与其他亚型无关。相反，较大的腹围与较高的管腔B型和TN型YOBC几率相关（分别为OR=1.48，95% CI 1.01-2.15和OR=2.48，95% CI 1.52-3.88），但与其他亚型无关（WHtR的结果类似）；奇数女性的几率最高：结论：研究结果表明，成人总体脂肪过多与管腔A型YOBC几率降低有关，而中心脂肪过多与管腔B型和TN型YOBC几率增加有关，特别是在奇偶女性中：影响：有必要对中心脂肪率和 YOBC 亚型风险进行更多研究，尤其是结合妊娠史。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.