Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.
Lisa A Ridnour, William F Heinz, Robert Y S Cheng, Adelaide L Wink, Noemi Kedei, Milind Pore, Fatima Imtiaz, Elise L Femino, Ana L Gonzalez, Leandro L Coutinho, Rebecca L Moffat, Donna Butcher, Elijah F Edmondson, Xiaoxian Li, Maria Cristina Rangel, Robert J Kinders, Jens Rittscher, Stanley Lipkowitz, Stephen T C Wong, Stephen K Anderson, Daniel W McVicar, Sharon A Glynn, Timothy R Billiar, Jenny C Chang, Stephen M Hewitt, Stefan Ambs, Stephen J Lockett, David A Wink
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Abstract
Significance: This work identifies CD8-NOS2+COX2+ and CD8-NOS2-COX2+ unique cellular neighborhoods that drive the tumor immune spatial architecture of CD8+ T cells predictive of clinical outcome and can be targeted with clinically available NOS inhibitors and NSAIDs.
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