Ironing out MAFLD: Therapeutic targeting of liver ferroptosis

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2024-10-01 DOI:10.1016/j.cmet.2024.09.005

Tuo Shao, Raymond T. Chung

引用次数: 0

Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) is associated with iron metabolism disorders and ferroptosis, but the mechanisms underlying this association remain unclear. Fudi Wang’s group¹ used animal models, human cohorts, and multi-omics data to demonstrate the role of iron imbalance in MAFLD and the therapeutic potential of the iron chelator FerroTerminator 1 (FOT1).

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熨平 MAFLD：以肝脏铁蛋白沉积为治疗目标

代谢功能障碍相关性脂肪肝（MAFLD）与铁代谢紊乱和铁变态反应有关，但这种关联的机制仍不清楚。王福弟研究小组1 利用动物模型、人类队列和多组学数据证明了铁失衡在 MAFLD 中的作用以及铁螯合剂 FerroTerminator 1 (FOT1) 的治疗潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.